能转化鹅去氧胆酸为熊去氧胆酸的厌氧菌的筛选  

THE ISOLATION OF ANAEROBES CAPABLE OF BIOTRANSFORMING CHENODEOXYCHOLIC ACID TO URSODEOXYCHOLIC ACID

作　　者：周德庆[1] 胡宝龙[1] 郑宣朋 黄爱珉 

机构地区：[1]复旦大学微生物学与微生物工程系 [2]上海市中药研究所 [3]暨南大学生物学系

出　　处：《复旦学报（自然科学版）》1990年第2期174-179,共6页Journal of Fudan University：Natural Science

基　　金：国家自然科学基金

摘　　要：熊去氧胆酸(ursodeoxycholic acid,UDCA)是熊胆的主要成分,也是治疗胆固醇结石的有效药物。本文采用自行设计的“针筒法”,从640份土样中筛出三株具有较高转化鹅去氧胆酸(chenodeoxycholic acid,CDCA)为UDCA能力的厌氧梭茵,并发现它们单独都具有UDOA生物转化能力。Ursodeoxycholic acid (UDCA), an effective and expensive medicine for trea-ting cholelithiasis, occurs in high concentration in the bile of bears. Using the'syringe method' designed by us, three strains of clostridia which transformedchenodeoxycholic acid (CDCA) to UDCA efficiently under anaerobic conditionswere isolated from 640 soil samples. It was found that they were capable ofconversing CDCA to UDCA independently.

关 键 词：熊去氧胆酸 鹅去氧胆酸 厌氧梭酸 

分 类 号：TQ464.5[化学工程—制药化工]