表面增强激光解析电离质谱筛选肿瘤标记物研究进展  

Advance in finding tumour marker with surface-enhanced laser desorption/ionization-time of flight mass spectrometry

作　　者：刘丽杰（综述）[1] 罗治文（审校）[1] 朱樑（审校）[1] 

机构地区：[1]第二军医大学第二附属医院消化科,上海200003

出　　处：《国际肿瘤学杂志》2007年第5期327-329,共3页Journal of International Oncology

基　　金：上海市科学技术委员会基金资助项目（011209014）

摘　　要：表面增强激光解析电离．飞行时间-质谱（SELDI-TOF—MS）近来被广泛应用于很多领域，尤其在寻找新的标记物方面，已有大量的文章报道发现不同的新标记物蛋白。人们逐渐意识到应该详细研究这些标记物的重复性，对其进行验证，研究它们的起源并进行鉴定。Surface-enhanced laser desorption/ionization-time of flight mass spectrometry （SELDI-TOF MS ）is used frequently in recent years, especially in finding tumour markers, and many new proteins are reported as biomarkers. However, it is increasingly recognized that reproducibility and validation of these biomarkers should be addressed carefully, as well as their origin and identity.

关 键 词：蛋白质组学 肿瘤标记 生物学 

分 类 号：R730.4[医药卫生—肿瘤]