Caveolin与脑功能关系的研究进展  

Progress of Caveolin and Its Role in Brain

作　　者：王璐[1] 嵇志红[2] 陈冬冬[1] 王红霞[1] 邹伟[1] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029 [2]大连大学医学院,大连116622

出　　处：《生物化学与生物物理进展》2007年第5期449-453,共5页Progress In Biochemistry and Biophysics

摘　　要：Caveolin作为细胞质膜微囊——Caveolae的标志蛋白,参与Caveolae的形成、定位,并具有介导膜泡运输、维持细胞胆固醇稳态和调控信号转导等功能.近年来发现,Caveolin与脑功能的生理或病理变化有关,在神经发育、突触可塑性以及神经退行性疾病中起着重要的作用.结合最新的研究进展和前期实验结果,简单介绍Caveolin的结构和功能,并对其在脑功能中的调控作用作一阐述与展望.Caveolins are a family of plasmalemmal vesicles caveolae-associated integral membrane proteins and a marker protein of caveolae involved in the formation and localization that associated with vesicular transport, cellular cholesterol homeostasis and signal transduction. Recent years, strong experimental evidences indicated that caveolins play a pivotal role in the brain function such as neural development, synaptic plasticity and neurodegenerative diseases. Recent progress on studies of the structure and functions of caveolins was simply summarized. The regulatory role of caveolins in the brain functions has been reviewed and expected.

关 键 词：CAVEOLIN 神经发育 突触可塑性 神经退行性疾病 

分 类 号：Q42[生物学—神经生物学]