海洋细菌Bacillus Marinus化学成分分离和结构鉴定  

Isolation and Structure Identification of Chemical Constituents from Marine Bacteria Bacillus Marinus

作　　者：尹宏权[1] 田黎[2] 付红伟[3] 华会明[3] 张青山[1] 裴月湖[3] 

机构地区：[1]北京理工大学化工与环境学院,北京100081 [2]青岛科技大学生物制药系 [3]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《北京理工大学学报》2007年第5期460-462,共3页Transactions of Beijing Institute of Technology

基　　金：国家"八六三"计划项目(2001AA624020)

摘　　要：研究Z3-1号海洋细菌bacillus marinus发酵液的化学成分.利用硅胶、Sephadex LH-20柱色谱及重结晶等方法进行分离纯化,根据理化性质和1H-NMR,13C-NMR等波谱数据进行结构鉴定.得到8个化合物,分别鉴定为环(甘氨酸-脯氨酸)二肽、环(丙氨酸-脯氨酸)二肽、环(亮氨酸-脯氨酸)二肽、对羟基氧代吡啶、尿嘧啶、胸腺嘧啶、β-谷甾醇和尿素.以上化合物均为首次从该种细菌发酵液中分离得到.Studies the chemical constituents of the fermentation liquid from marine bacteria bacillus marinus （No. Z3-1）. The compounds were isolated by column chromatography on silica gel, Sephadex LH-20 and recrystallization. Their structures were determined on the basis of physico-chemical properties and spectroscopic methods such as ^1H-NMR and ^13C-NMR. Eight compounds separately were identified as cyclo-（Gly-Pro） dipeptide, cyclo-（Ala-Pro） dipeptide, cyclo-（Leu-Pro） dipeptide, 4-hydroxy-1-oxy-pyridine, uracil, thymine, β-sitosterol and urea. These compounds were obtained from bacillus rnarinus for the first time.

关 键 词：药物化学 成分分离 结构鉴定 海洋细菌 BACILLUS marinus 

分 类 号：R931.77[医药卫生—生药学]