鄂温克民族X染色体遗传结构及遗传关系  

Genetic structure of X-STR loci of Ewenki nationality and its affinity with other nationalities

作　　者：侯巧芳[1] 李晓钟 通木尔 荣辽江 张冉 王旭军 李生斌[1] 

机构地区：[1]西安交通大学医学院卫生部法医学重点实验室,西安710061 [2]内蒙古自治区人民检察院,呼和浩特010010 [3]内蒙古自治区高级人民法院,内蒙古自治区010020 [4]内蒙古自治区公安厅,呼和浩特010051

出　　处：《中南大学学报（医学版）》2007年第2期276-281,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(39970401);教育部科技平台项目(505015)~~

摘　　要：目的:研究内蒙古鄂温克族人群9个X-STR位点的多态性分布及群体遗传学、法医学应用价值。方法:选择9个X-STR(DXS6804,DXS7133,DXS101,DXS6789,DXS6799,DXS7423,HPRTB,DXS8378,DXS7132),分析其多态性分布及与其他群体间的遗传距离和聚类关系。结果:研究群体中共检出51种等位基因,频率分布在0.0109～0.6863;基因型频率分布在0.0217～0.3778之间;杂合度、个体识别率、多态性信息量等群体遗传学指标分析显示,9个STR位点具有中度或高度多态性;聚类分析和系统进化关系分析发现,鄂温克族相对于内蒙古地区其他3个民族和西安汉族具有较独立的遗传结构。结论:所选择9个X-STR位点具有较高的个体识别率和多态性信息量,可用于群体遗传学和法医学研究。Objective To determine the genetic diversity of X-STR loci, and to evaluate the genetic structure X chromosome＇ s of Ewenki nationality and its affinity with other nationalities. Methods We chose 9 X-STR（ DXS6804 ,DXS7133 ,DXS101 ,DXS6789 ,DXS6799 ,DXS7423, HPRTB ,DXS8378 ,DXS7132 ） as genetic markers from 99 irrelative individules to determine the genetic diversity of Ewenki in Inner Mongolian. Cluster analysis and phylogenic trees was applied to show the genetic distance among the nationalities. Results We got 51 alleles in the studied population, with the frequency diverse between 0.0109 and 0. 6863. Genotype frequency was from 0.0217 to 0. 3778. Heterozygosity （ H ） , the power of discrimination （ PD ） and the polymorphism information conten （PIC） were consistent with the forensic application. Cluster analysis and phylogenic trees revealed that Ewenki nationality had estrangement genetic affinity with the other 3 major nationalities in inner mongolia and Han nationality in Xi＇ an. Conclusion The genetic information demonstrates that the 9 chosen gene makers were highly informative loci and are suitable for population genetics research and forensic application.

关 键 词：X染色体STR 遗传多态性 遗传距离 聚类分析 鄂温克族 

分 类 号：R394.5[医药卫生—医学遗传学]