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作 者:俞惠新[1] 王铁生[1] 林秀峰[1] 齐效君[1] 谭成[1] 陈波[1] 张莉[1] 曹国宪[1] 王博诚[1]
机构地区:[1]江苏省原子医学研究所
出 处:《肿瘤防治研究》2007年第5期331-333,I0002,共4页Cancer Research on Prevention and Treatment
摘 要:目的探讨埃本膦酸钠对肺癌细胞骨转移动物模型的干预作用。方法通过贴骨接种人小细胞肺癌H446细胞制作骨转移动物模型,皮下注射埃本膦酸钠干预,利用放射学检查及病理分析等手段观察埃本膦酸钠对肺癌细胞骨转移的干预效果。结果放射学检查显示裸鼠接种H446细胞后引起明显的肿瘤性骨损伤,骨病灶处的99Tcm-MDP放射性浓聚,肿瘤细胞大量侵袭至骨髓腔中。经埃本膦酸钠干预后,此骨损伤病程被明显抑制。结论埃本膦酸钠可明显地干预肿瘤细胞对骨的侵犯,减轻肿瘤引起的骨损伤,可作为一个治疗骨转移的选择药物。Objective To investigate the inhibiting ability of Ibandronate on a skeletal metastasis model of lung caner. Methods A skeletal metastasis model of lung caner was established by injection of small cell lung carcinoma line(SCLC) H446 cells into the right leg of nude mice proximally to the tibia, and Ibandronate(5μg/animal/day) was given subcutaneously(s, c. ) to the animals after radiologically small but defined osteolytic metastases were observed. Both X-ray and histological assay were applied to evaluate effects of Ibandronate. Results Both X ray detection and ^99Tc^m-MDP imaging demonstrated that implant of H446 caused the development of bone lesions. Histological studies showed abnormal reacting bone formation preceded by tumor metastasizing and a number of cancer cells invading into bone marrow. But in the treated group, Ibandronate not only markedly suppressed the progression of established bone metastases lesions in nude mice, but also prevented the development of lung cancer cells in bone marrow. The reacting bone formation was limited locally. Conclusion These results suggest that Ibandronate may be a choice for the treatment of metastasis cancer in bone.
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