Ⅰ期原发性肝癌三维适形放疗的疗效评价和预后多因素分析  

Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for StageⅠ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis

作　　者：张洪波[1] 陈龙华[1] 吴德华[1] 曹小飞[1] 

机构地区：[1]南方医科大学附属南方医院肿瘤放射治疗科,广州510515

出　　处：《肿瘤防治研究》2007年第5期378-381,共4页Cancer Research on Prevention and Treatment

基　　金：广东省科技计划基金资助项目(2004B30301011);广东省自然科学基金资助项目(批准号2005004776)

摘　　要：目的评价三维适形放疗(3-dimensional conformal radiation therapy,3-DCRT)对Ⅰ期原发性肝癌治疗疗效及其影响预后的因素分析。方法对41例Ⅰ期原发性肝癌患者行三维适形放疗,用kap-lan-Meier统计累积生存率、COX回归模型对预后进行单、多因素分析。结果1、2、3年累积生存率分别为95.1%、90.2%、80.5%。平均生存时间49.5月。中位生存时间56个月。治疗副反应轻微。多因素回归分析显示仅肿瘤数目对患者生存期的影响有统计学意义(P<0.05)。结论三维适形放疗对Ⅰ期原发性肝癌患者的治疗是安全、有效的手段,肿瘤数目、肿瘤直径是影响预后的主要因素。Objective To evaluate the therapeutic effects of 3-dimensional conformal radiationtherapy for small hepatocellular carcinoma and analyze the prognostic factors. Methods Forty-one cases of small hepatocellular carcinoma were treated with three-dimensional conformal radiotherphy,The Kaplan-Meier was used to evaluate the survival rates, and the COX regression model was used to analysis single and multi-factors of the prognosis. Results The overall 1-, 2 , 3-year survival rate were 95. 1%、 90. 2%、 80. 5%respectively. Mean survival time was 49. 5 months, Media survival time was 56 months. The side effects of radiotherapy could be tolerated. Multi-factors analysis revealed that the number and the diameter of tumor were independent prognostic factors affecting the patients＇ survival（P〈0.05）. Conclusion The results suggest that three-dimensional conformal radiotherapy for Stage Ⅰ hepatocellular carcinoma is a relatively safe and effective method. The number and the diameter of tumor were independent prognostic factors affecting the patients＇ survival.

关 键 词：原发性肝癌 三维适形放疗 疗效 多因素分析 

分 类 号：R735.7[医药卫生—肿瘤] R730.55[医药卫生—临床医学]