宫颈癌组织中Survivin、Fas与FasL蛋白的表达  

Expression of Survivin, Fas, and FasL in cervical cancer tissue

作　　者：徐虹[1] 蒋东霞[1] 胡杰英[1] 马杰[2] 王丽[2] 周云[3] 

机构地区：[1]河南省肿瘤研究所,郑州450003 [2]河南省肿瘤医院病理科,郑州450003 [3]河南省人民医院肿瘤科,郑州450003

出　　处：《郑州大学学报（医学版）》2007年第3期496-498,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科研机构专项基金资助项目0441130406

摘　　要：目的检测宫颈鳞状细胞癌(SCC)组织中Survivin、Fas及FasL蛋白的表达。方法采用免疫组化法检测8例正常宫颈组织、13例不典型增生(CIN)组织和36例SCC组织中Survivin、Fas与FasL蛋白的表达。结果正常宫颈组织Survivin蛋白的阳性表达率为0.00%,CIN为53.64%,SCC为94.44%,3组间相比,差异均有统计学意义(P<0.05);正常宫颈组织Fas蛋白的阳性表达率(87.50%)与CIN(46.15%)和SCC(44.44%)相比差异均有统计学意义(P<0.05);正常宫颈组织FasL蛋白阳性表达率(25.00%)低于CIN(61.53%)和SCC(55.56%)组织(P<0.05)。结论在宫颈细胞的恶变和进展过程中,失控的Fas与FasL系统和与其相关的Survivin的表达对细胞逃逸凋亡起重要作用。Aim ： To detect the expression of Survivin, Fas and FasL in cervical squamous cell carcinoma（SCC） tissue. Methods：The expressions of Survivin, Fas and FasL in 8 cases of normal cervix, 13 cases of cervical intraepithelial neoplasia （CIN） and 36 cases of SCC tissue were detected by immunohistochemistry. Results： The positive rates of survivin in normal cervix, CIN and SCC tissue were 0.00% , 53.64% , 94.44% , respectively, and there was significant difference between each 2 groups （ P 〈 0.05 ）. The positive rate of Fas in normal cervical tissue （ 87.50% ） was significantly higher than that in CIN （46.15%） and SCC （44.44%） , P 〈0.05. The positive rate of FasL in normal cervical tissue （25.00%） was significantly lower than that in CIN （61.53%） and SCC （55.56%） , P 〈 0.05. Conclusion： Deregulated Fas/FasL system and expression of Survivin in SCC may play an important role in the development of SCC.

关 键 词：宫颈鳞状细胞癌 SURVIVIN FAS FASL 

分 类 号：R737[医药卫生—肿瘤]