胰腺癌组织中乙酰肝素酶蛋白的表达  

Expression of heparanase in pancreatic carcinoma tissue

作　　者：张浩[1] 僧靖静[2] 赵玉亭[1] 李伟汉[1] 

机构地区：[1]南阳市中心医院普外科,南阳473000 [2]郑州大学第一附属医院普外科,郑州450052

出　　处：《郑州大学学报（医学版）》2007年第3期568-569,共2页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的研究胰腺癌组织中乙酰肝素酶(heparanase,HPA)蛋白的表达及其临床意义。方法应用免疫组织化学SP法检测27例胰腺癌组织(Ⅰ期4例,Ⅱ期8例,Ⅲ期11例,Ⅳ期4例;有淋巴结转移者18例,无淋巴结转移9例)、11例癌旁组织中HPA蛋白的表达情况,并对其表达与临床病理特征进行分析。结果胰腺癌组织中HPA蛋白阳性表达率为70.1%(19/27),高于癌旁组织(9.1%,1/11)(P<0.05)。淋巴结转移组HPA蛋白阳性表达率(83.3%,15/18)高于无淋巴转移组(55.6%,5/9)(P<0.05)。Ⅰ+Ⅱ期组HPA蛋白阳性表达率(66.7%,8/12)低于Ⅲ+Ⅳ组(80.0%,12/15)(P<0.05)。结论HPA的异常表达与胰腺癌的发生、发展密切相关,可能是影响胰腺癌预后的重要分子指标。Aim： To investigate the expression of heparanase （HPA） in pancreatic carcinoma tissue and its clinical significance. Methods：The expression of HPA was detected using immunohistochemistry SP method in 27 cases of pancreatic carcinoma, and 11 cases of adjacent normal pancreatic tissue. Results： In pancreatic carcinoma tissue, the positive rate of HPA expression （70.1% , 19/27） was remarkably higher than that in normal pancreatic tissue （9.1% , 1/11 ） （ P 〈 0.05）. Tumors with lymph node metastasis had higher HPA protein expression （83. 3%, 15/18） than that without （55.6% , 5/9） （ P 〈 0. 05）. The HPA expression of tumor tissue at Ⅰ＋Ⅱ stage （66.7% ,8/12） was significantly lower than that at Ⅲ＋Ⅳ stage（80.0% ,12/15）, P 〈 0. 05. Conclusion： The abnormal expression of HPA correlates with the occurrence and development of pancreatic carcinoma. HPA is an important prognostic indicator of pancreatic carcinoma.

关 键 词：胰腺肿瘤 乙酰肝素酶 

分 类 号：R735.9[医药卫生—肿瘤]