肠易激综合征患者乙状结肠黏膜内5-羟色胺的作用  

The role of 5-hydroxytryptamine on sigmoid mucosa in irritable bowel syndrome

作　　者：王斌[1] 顾晓红[1] 刘玲[2] 蔡敏[1] 程峰涛[1] 李力[1] 

机构地区：[1]上海市杨浦区中心医院消化科,200090 [2]上海市杨浦区中心医院病理科,200090

出　　处：《中国医药》2007年第5期278-280,共3页China Medicine

摘　　要：目的研究肠易激综合征（IBS）患者结肠黏膜5-羟色胺的分布情况,进一步探讨两者之间的关系。方法选择腹泻型和便秘型IBS患者和健康对照者,在电子肠镜下取升结肠、乙状结肠以及直肠黏膜活检,采用免疫组化方法观察5-羟色胺在结肠黏膜中的分布情况。结果与对照组相比,便秘组结肠5-羟色胺分布差异无统计学意义（P〉0.05）。腹泻组升结肠段、直肠段5-羟色胺多于对照组,但无统计学意义（P〉0.01）;乙状结肠段5-羟色胺分布明显多于对照组（P〈0.05）。结论腹泻型IBS乙状结肠5-羟色胺分布明显增多,说明乙状结肠5-羟色胺增多可能在腹泻型IBS的发病机制中起重要作用。Objective To investigate the distribution of 5-hydroxytryptamine （5-HT） on sigmoid mucosa in patients with irritable bowel syndrome （IBS） by immunohistochemistry methods and further explore the role of 5-HT on IBS. Methods Diarrhea-IBS and constipation-IBS group and health control group were selected. Mucosa in ascending colon, sigmoid colon and rectum were taken in both groups. The distribution of 5-HT in colon mucosa was observed by immunohistochemistry methods. Results The distribution of 5-HT did not vary significantly in constipation-IBS group and control group （ P 〉 0.05 ）. The 5-HT on ascending colon and rectum in Diarrhea-IBS group was more than that of control group, but without statistical significance （P 〉 0.01 ）, but the distribution of 5-HT on sigmoid colon in Diarrhea-IBS group is much more than that of control group （ P 〈 0.01 ）. Conlusion The distribution of 5-HT on sigmoid colon in Diarrhea-IBS group is increased significantly, which indicates that these changes may play important roles in the pathogenesis of Diarrhea-IBS patients.

关 键 词：肠易激综合征 5-羟色胺 乙状结肠 免疫组化技术 

分 类 号：R574.4[医药卫生—消化系统]