血管新生对多发性骨髓瘤预后的判定意义  

Significance of Angiogenesis in Prognosis of Multiple Myeloma Diagnosed Newly

作　　者：李欣[1] 杨光忠[1] 赵宏颖[2] 陈文明[1] 

机构地区：[1]首都医科大学附属北京朝阳医院血液科,北京100020 [2]首都医科大学附属北京朝阳医院病理科,北京100020

出　　处：《中国误诊学杂志》2007年第11期2434-2436,共3页Chinese Journal of Misdiagnostics

基　　金：本课题获北京市科技新星计划基金项目部分资助(编号:954812300)

摘　　要：目的:探讨骨髓微血管密度(microvessel density,MVD)对多发性骨髓瘤(multiple myeloma,MM)预后判定的意义。方法:选取57例新诊断MM患者,在治疗前接受骨髓活检,应用免疫组化法测定骨髓MVD;同时对患者进行随访4 a以上。结果:新诊断MM患者的骨髓MVD与疾病国际预后分期(ISS)相关,期>期>期(P<0.01);高MVD者预后显著差于低MVD患者。结论:提示血管新生旺盛的MM患者预后不良;通过测定骨髓MVD可以初步评价患者预后。Objective：To detect the microvessel density （MVD） in newly diagnosed multiple myeloma （MM）, and analyze the relationships between angiogenesis and the prognosis of MM. Methods：Fifty-seven patients with MMdiagnosed newly were studied. MVD was detected by immunohistochemistry. All the patients were followed up for 4 years. Results ：According to the International Staging System （ISS）, the MVD in the patients diagnosed newly was correlated with disease stage and MVD in stage Ⅲ was statistically higher than that stage Ⅰ/Ⅱ . The prognosis was worse in patients with higher MVD than that with lower MVD. Conclusions：Angiogenesis may play an important role in prognosis of newly diagnosis MM which can give a preliminary result by detecting MVD.

关 键 词：多发性骨髓瘤/血液供给 新生血管化 病理性 预后 

分 类 号：R733.3[医药卫生—肿瘤]