血浆同型半胱氨酸与缺血性脑血管病关系的研究  

Study on the relationship between plasm concentration of Homocysteine(Hcy) and ischemic cerebrovascular disease

作　　者：杨致远[1] 李亚娟[1] 马聪敏[1] 

机构地区：[1]河南洛阳市中心医院神经内科,洛阳471009

出　　处：《中国实用神经疾病杂志》2007年第3期1-3,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑血管病的关系。方法将87例患者分为缺血性脑血管病组(67例,其中脑梗死组45例,短暂性脑缺血发作组22例)和对照组(20例),检测所有受试对象血浆Hcy水平并记录患者的脑血管病传统危险因素。分析血浆Hcy与缺血性脑血管病的相关性。结果与血浆Hcy水平在最低四分位人群相比,处于较高四分位者患缺血性脑血管病的比值比(OR)为5·278(95%CI为1·203～23·158,P<0·05);处于最高四分位者患缺血性脑血管病的比值比(OR)为7·917(95%CI为1·473～42·538);与非高同型半胱氨酸血症(Hhcy)患者相比,Hhcy患者患缺血性脑血管病的OR值为4·325(95%CI为1·156～16·174,P<0·05);缺血性脑血管病组、脑梗死组与TIA组患者血浆Hcy水平均高于对照组(P<0·05),但脑梗死组与TIA组血浆Hcy水平相比较无差异(P>0·05);采用多因素Logistic回归分析,血浆Hcy进入模型。结论血浆Hcy水平升高可能是与传统危险因素无关的缺血性脑血管病的独立危险因素,我们有必要制订出适合于中国人的Hhcy的诊断标准。Objective To investigate the relationship between plasm concentration of Homocysteine（Hcy） and ischemic cerebrovascular disease . Methods 87 patients, 67 in ischemic cerebrovascular disease group（involving 45 patients with cerebral infarction and 22 patients with TIA）, and 22 in control group ,were collected. Plasma concentration of Hcy was detected and the traditional risk factors of cerebrovascular disease were recorded. Results People in lowest quarter intake of plasma concentration of Hcy had lower risk of ischemic cerebrovascular disease than those in the higher quarter（OR= 5. 278, 95 % CI.1. 203 -23. 158, P〈0. 05）, as well as than that in the highest quarter（OR= 7. 917,95 % CI： 1. 473 - 42.538, P〈0.05）. Comparing with non- Hyperhomocysteinemia（Hhcy ） patients, the patients with H hcy had a significant higher risk of ischemic cerebrovascular disease（OR= 4. 325,95 %CI： 1. 156-16. 174,P〈0.05）. Plasma concentration of Hcy in the ischemic cerebral disease group , cerebral infarction group and TIA group were all significant higher than that in the controlled group. However, there was no significant difference in the plasm concentration of Hcy between cerebral infarction group and TIA group. Mutivariable logistic regression showed plasma Hcy was independent risk factor of cerebral infarction. Conclusion The increase of plasma concentration of Hcy may be not related with traditional risk factors and it may be an independent risk factor of ischemic cerebrovascular disease. We should build a diagnostic standard for Hhcy which is fit for chinese people.

关 键 词：同型半胱氨酸 高同型半胱氨酸血症 缺血性脑血管病 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]