卒中后抑郁、焦虑的干预和预后临床分析  

Clinical study of treatments and prognosis on depression and anxiety after stroke

作　　者：黄玉莹 李少清 李郭飞[2] 赵秀红 

机构地区：[1]河南开封陇海(脑科)医院神经内科,开封475003 [2]河南大学附属淮河医院神经内科,开封475003 [3]河南开封市精神病医院,开封475003

出　　处：《中国实用神经疾病杂志》2007年第3期25-26,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨脑卒中后抑郁、焦虑对患者日常生活能力和神经功能康复的影响,帕罗西汀干预急性卒中后抑郁、焦虑的效果。方法对282名脑卒中患者采用抑郁自评量表(SDS)、焦虑自评量表(SAS)进行评定,其中卒中后抑郁合并焦虑的90名随机分为干预和非干预2组,干预组接受帕罗西汀治疗;随机抽取非抑郁、焦虑患者45名为对照组,用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、斯堪的那维亚脑卒中量表(SSS)、Barthel指数(BI),评定帕罗西汀的疗效和预后。结果急性脑卒中后抑郁合并焦虑发生率(68.18%),非干预组与对照组比较6周末SSS和BI有显著性差异(P<0·01),干预组与对照组SSS和BI无显著性差异,干预组与非干预组HAMD、HAMA、SSS、BI有显著性差异。结论抑郁、焦虑明显降低患者神经功能康复程度和生活能力恢复,帕罗西汀可有效干预卒中后抑郁、焦虑,改善预后。Objective To investigate the effects of post-stroke depression and anxiety on ability of daily life and nerve function rehabilitation ,to study the therapeutic effects of Paroxetine on depression and anxiety in acute stroke. Methods The data in 282 patients with acute stroke were assessed by SDS and SAS, in which the 90 papatients with depression and anxiety were divided into two groups randomly , one of them were treated with Paroxetine others were not treated. 45 patients not depression and anxiety as control group randomly. HAMD, HAMA,SSS,BI were assessed to observe the curative effect triter treated with Paroxetine. Results The attack rate of depression combined with anxiety in acute stroke was 68.18%. The difference of grade on reducing of SSS and increasing of BI in not treated group and control group were obviously（P〈0. 01）after six weeks, the grade of SSS , BI in treated group and control group was no significant difference . The difference of HAMD, HAMA, SSS, BI in treated group and no treated group（P〈0.01）. Conclusion Post- stroke depression and anxiety can obvious reduced the ability of daily life and nerve function rehabilitation. The patients＇ ability of daily life and the degree of neurologic functional rehabilitation all can be increased by applying Paroxetine.

关 键 词：脑卒中 抑郁 焦虑 帕罗西汀 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]