大肠正常粘膜、腺瘤及癌组织中VEGF及其受体Flk-1表达的意义  

The significance of VEGF Flk-1 expression in normal nucosa,adenoma and colorectal carcinoma

作　　者：石艳华[1] 叶红[2] 关丽华[2] 申兴斌[1] 龚秀云[2] 王瑞婷[1] 

机构地区：[1]承德医学院,河北省承德市067000 [2]承德医学院附属医院

出　　处：《河北医药》2007年第2期107-108,共2页Hebei Medical Journal

基　　金：承德市科技局资助项目(编号:20031018);河北省科技厅指导性课题(编号:032761138)

摘　　要：目的探讨血管内皮生长因子(VEGF)及其受体Flk-1在大肠癌发生中的作用。方法采用免疫组化技术检测正常大肠粘膜15例(NM组)、大肠腺瘤27例(Ad组)、大肠癌81例(CC组)中VEGF及其受体Flk-1的表达。结果从NM到Ad到CC组VEGF及其受体Flk-1的表达逐渐增高、增强组间均存在显著差异(P均<0.01)。结论VEGF及其受体Flk-1可作为大肠正常组织恶变的不良信号,检测VEGF及其受体Flk-1可作为预测组织恶变的参考指标。Objective To investigate the significance of VEGF and its receptor Flk-1 expression in normal mucosa （NM）, adenoma and colorectal carcinoma（CC）. Methods SP immunohistochemical staining was used to examine expressions of VEGF, Flk-1 among 15 cases of NM, 27 cases of Ad and 81 cases of CC paraffin-embedded specimens. Rank sum test was used to analyze the expressions of VEGF and Flk- 1. Results The expression of VEGF and Flk-1 from NM to Ad to CC appeared an upward tendency. There were significant differences in VEGF and Flk- 1 expression between the two groups（ P 〈0.01, P 〈0.01）. Conclusions VEGF,Flk-1 as bad signals in the occurrence of CC could be regarded as predictive factors of CC.

关 键 词：大肠癌 血管内皮生长因子 FLK-1 免疫组化 

分 类 号：R743.31[医药卫生—神经病学与精神病学]