氨己烯酸对自发性癫痫大鼠小发作和大发作的作用  

Effects of vigabatrin on absence-like seizures and tonic convulsions in spontaneously epileptic rats

作　　者：聂宏光[1] 蔡际群[1] 姚维范[1] 

机构地区：[1]中国医科大学药学院药理学教研室,辽宁沈阳110001

出　　处：《中国药理学通报》2007年第5期597-600,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题(No30270535)

摘　　要：目的研究氨己烯酸对自发性癫痫大鼠的小发作和大发作的作用。方法通过在自发性癫痫大鼠大脑海马和皮质部位安插电极,观察口服氨己烯酸后对自发性癫痫大鼠的脑电图的影响。结果口服氨己烯酸(100mg·kg-1)后3、4、5h癫痫小发作的出现频率分别下降到给药前的(54±5)%、(41±9)%和(34±4)%(P<0.01)。氨己烯酸使大发作的出现频率分别下降到给药前的(68±13)%、(39±13)%和(21±6)%(P<0.01)。氨己烯酸的抑制效应能被GABAA受体特异性拮抗剂荷包牡丹碱拮抗。结论氨己烯酸具有明显的对抗自发性癫痫大鼠的小发作和大发作的作用,对癫痫大发作的抑制效应是通过GABAA受体发挥作用的。Aim To study effects of vigabatrin on absence-like seizures and tonic convulsions in spontaneously epileptic rats （SERs）. Method Electrcorticogram and depth electroencephalographic activity in hippocampus of SERs were recorded with implanted electrodes after administration of vigabatrin. Results The number of absence-like seizures was significantly reduced from 100% to （54 ±5）%, （41 ±9）% and （34 ±4）% （P 〈0.01, compared with control） at 3 h, 4 h and 5 h after vigabatrin （ 100 mg · kg^-1 ） administration. When vigabatrin was administered at a dose of 250 mg · kg^-1, the frequency of tonic convulsions also significantly decreased from 100% to （68 ± 13）%, （39 ±13）% and （21 ±6）%, respectively （P 〈0. 01, compared with control）. At doses of 100 and 250 mg·kg^-1 of vigabatrin, a significant inhibition of both tonic convulsions and absence-like seizures were observed at 5 h after administration. In contrast a dose of 50 mg·kg^-1 of vigabatrin had no significant effect on the tonic convulsions and absence-like seizures. The inhibitory effects of vigabatrin on tonic convulsions could be antagonized by bicuculline, a GABA （A） receptor antagonist. Conclusion Vigabatrin is effective for treatment of absence-like seizures and tonic convulsions in SERs.

关 键 词：氨己烯酸 自发性癫痫大鼠 癫痫小发作 癫痫大发作 

分 类 号：R-332[医药卫生] R322.81