妥泰加用治疗成人难治性部分性癫痫  

Topiramate as adjunctive therapy in 52 adults with refractory partial epilepsy

作　　者：李艳明 谢菊生[2] 

机构地区：[1]湖南省湘潭市三医院神经内科,湖南湘潭421001 [2]湖南省郴州市第一人民医院神经内科,湖南郴州423000

出　　处：《中国医学工程》2007年第3期274-276,共3页China Medical Engineering

摘　　要：目的观察妥泰加用治疗成人难治性部分性癫痫的疗效及安全性。方法对52例难治性部分性癫痫患者进行妥泰添加治疗20周以上,以治疗前12周的发作频率为基础,与评价前12周的发作频率进行自身对照研究,并观察不良反应的发生。结果发作完全控制7例(13.4%),发作减少≥75%14例(26.9%),发作减少≥50%11例(21.2%),发作减少<50%20例(38.5%)。单纯部分性发作和复杂部分性发作的疗效无明显差别。治疗过程中无严重不良反应。结论妥泰加用治疗成人难治性部分性癫痫安全有效,耐受性好。[Objective] To observe the effects and safety of Topiramate as adjunctive therapy for adults with refractory partial epilepsy. [Methods] TPM was adapted as adjunctive therapy in 52 cases for over 20 weeks. The efficacy was assessed by comparing the average frequency of 12 weeks before assessment to the baseline frequency before treatment, and the adverse events were recorded. [Results] The seizure in 7 cases （13.4%） was totally controlled, seizure reduction ≥75% in 14 cases （26.9%）, ≥50% in 11 cases （21.2%）, and 〈50% in 20 cases （38.5%）. The effectiveness between simplex and complex partial epilepsy had no difference. There was no severe side-effects during the course of treatment. [Conclusion] TPM is a safe and effective drug for treating adult patients with re- fractov partial epilepsy.

关 键 词：妥泰 加用治疗 难治性部分性癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]