白细胞介素-1受体拮抗剂基因型2/2与白塞病葡萄膜炎易感性的相关研究  

Association of IL-1 receptor antagonist gene 2/2 genotype with increased susceptibility for Behcet′s disease with uveitis

作　　者：刘相东[1] 孙善会[2] 肖东杰[2] 牟国营[3] 汪运山[2] 

机构地区：[1]山东大学山东省立医院检验科,山东济南250021 [2]山东大学济南市中心医院医学实验诊断中心,山东济南250013 [3]山东大学济南市中心医院眼科,山东济南250013

出　　处：《山东大学学报（医学版）》2007年第5期467-469,共3页Journal of Shandong University:Health Sciences

基　　金：山东省科技发展基金资助课题(012130117)

摘　　要：目的:探讨白细胞介素-1受体拮抗剂(IL-1ra)基因多态性与白塞病(Behcet′s disease,BD)葡萄膜炎间的相关性。方法:应用测定短串联重复序列的PCR技术,对27例BD患者和71例健康对照组IL-1ra基因多态性进行测定。结果:BD患者和对照组之间的IL-1ra等位基因和基因型频率差异无统计学意义(P>0.05)。基因型2/2能增加BD葡萄膜炎易感性(OR=3.3)。其他IL-1ra基因型或基因频率与BD葡萄膜炎无关。结论:IL-1ra基因型2/2与增加BD葡萄膜炎易感性有关。Objective： To investigate a possible association of specific polymorphisms of interleukin 1（IL-1） receptor antagonist （IL-1ra） genes with susceptibility for Behcet＇s disease （BD） with uveitis. Methods： The genotypes of a total of 27 BD patients and 71 controls were determined for IL-1ra variable number of tandem repeat polymorphisms （for five different alleles） by PCR. Х^2-analysis was used to compare the allele and genotype frequencies of patients and controls. Results： There was no difference in the allele or genotype frequencies of IL-1ra between patients with BD and the controls （P 〉0.05）. The 2/2 genotype of IL-1ra polymorphisms was identified as an increased risk of BD with uveitis（ OR = 3.3）. No association was produced for other investigated polymorphisms in the genotype or allele frequencies of IL-1ra between the BD patients or BD patients with uveitis and the control. Conclusion： Susceptibility to BD with uveitis is enhanced in individuals carrying the 2/2 genotype of IL-1ra polymorphisms.

关 键 词：贝赫切特综合征 葡萄膜炎 白细胞介素-1 基因型 

分 类 号：R773[医药卫生—眼科] Q754[医药卫生—临床医学]