Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index  

作　　者：XIANG Yan LI Yu-hong 

机构地区：[1]Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2007年第6期428-434,共7页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project (No. 419200-584602) supported by the Start Foundation for Introducing Talent of Zhejiang University, China

摘　　要：Objective： To compare the effects of epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine on propofol requirements, the time to loss of consciousness （LOC）, effect-site propofol concentrations, and the hemodynamic variables during induction of general anesthesia guided by bispectral index （BIS） were studied. Methods： Forty-five patients were divided into three groups to receive epidurally administered saline （Group S）, 1.5% （w/w） lidocaine （Group L）, or 0,5% （w/w） ropivacaine （Group R） Propofol infusion was started to produce blood concentration of 4 lag/ml. Once the BIS value reached 40-50, endotracheal intubation was facilitated by 0.1 mg/kg vecuronium. Measurements included the time to LOC, effect-site propofol concentrations, total propofol dose, mean arterial blood pressure （MABP）, and heart rate （HR） at different study time points. Results： During induction of anesthesia, both Groups L and R were similar for the time to LOC, effect-site propofol concentrations, total propofol dose, MABP, HR, and BIS. The total doses of propofol administered until 1 min post-intubation were significantly less in patients of Groups R and L compared with Group S. MABP and HR were significantly lower following propofol induction compared with baseline values in the three groups, or MABP was significantly increased following intubation as compared with that prior to intubation in Group S but not in Groups R and L while HR was significantly increased following intubation in the three groups. Conclusion： Epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine has similar effects on the time to LOC, effect-site propofol concentrations, total propofol dose, and the hemodynamic variables during induction of general anesthesia.客观：为了把硬膜上的麻醉的效果与 1.5% lidocaineand 作比较， propofol 要求，知觉(LOC ) 的损失的时间， effect-sitepropofol 集中，和在一般麻醉的正式就职期间的血液动力学的变量上的 0.5% ropivacaine 由双性人指导了光谱索引(二度) 被学习。方法：45 个病人被划分成三个组硬膜上地收到管理盐(组 S ) ， 1.5%(w/w ) lidocaine (组 L ) ，或 0.5%(w/w ) ropivacaine (组 R ) 。 Propofol 注入开始被生产 BIS 价值到达了的 4 μg /ml.Once 的血集中 40 ～5 0 ，气管内膜的 intubation 被包括的 0.1 mg/kg vecuronium.Measurements 便于 LOC 的时间，效果地点 propofol 集中，全部的 propofol 剂量，吝啬的动脉的血压( MABP )，并且在不同学习时间的心率( HR )指。结果: 在 LOC， effect-sitepropofol 集中，全部的 propofol 剂量， MABP， HR，和二度的时间在麻醉，两组 L 和 R 的正式就职期间是类似的。propofoladministered 的全部的剂量是直到 1 min post-intubation 显著地在有组 S 的组 R 和 Lcompared 的病人的更少。MABP 和 HR 显著地更低在三个组跟随与基线价值相比感应的 propofol，否则当 HR 显著地被增加时， MABP 在在组 S 然而并非在组 R 和 L 的 intubation 以前与那相比是显著地增加的后面的 intubationas 在三个组跟随 intubation。结论：有 1.5% lidocaine 和 0.5% ropivacaine 的硬膜上的麻醉在一般麻醉的正式就职期间在 LOC， effect-sitepropofol 集中，全部的 propofol 剂量，和血液动力学的变量的时间有类似的效果。

关 键 词：PROPOFOL LIDOCAINE ROPIVACAINE Epidural anethesia Bispectral index 

分 类 号：R614[医药卫生—麻醉学] R971.2[医药卫生—外科学]