诱导吲哚胺2,3-二加氧酶表达的信号通路  

Signaling pathways inducing expression of idoleamine 2,3-dioxygenase

作　　者：刘小会[1] 刘鹏[1] 杜军[1] 

机构地区：[1]中山大学药学院微生物与生化制药实验室,广东广州510080

出　　处：《中华肿瘤防治杂志》2007年第9期719-722,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：吲哚胺2,3-二加氧酶(idoleamine2,3-dioxy-genase,IDO)的高表达是导致肿瘤免疫耐受的一个重要机制。诱导IDO的表达具有两种信号传导途径。一种是干扰素依赖途径,即IDO在Th-1型细胞因子干扰素、CpG ODNs等刺激后优先在巨噬细胞和树突状细胞等中表达,这种途径主要是由信号传导子及转录激活因子1α(STAT1α)和干扰素调节因子1(IRF-1)介导。另一种则是干扰素非依赖途径,即IDO在LPS等刺激后在人外周血单核细胞(PBMC)和人类急性单核白血病细胞(THP-1)等中表达,这种途径可能与p38MAPK通路及NF-κB通路有关。明确IDO的信号通路且调控其表达,可为肿瘤的免疫治疗提供新策略。Over expression of indoleamine 2, 3-dioxygenase （IDO） is an important mechanism that is responsible for immune tolerance of tumor. The expres sion of IDO is known to be induced by interferon-media ted effects of the signal transducer and actiwltor of transcription 1α（STAT1α） and interferon regulatory factor （ IRF）-1. Moreover, IDO expression can also be induced by I,PS in human PBMC and THP 1 ceils through an in terferon independent mechanism, which may he related to the p38 MAPK and NF-κB pathway. Clarifying these signaling pathways and interactions of relevant cytokines might hell/3 to improve tumor therapy.

关 键 词：吲哚类 色氨酸加氧酶 信号传导 综述文献 

分 类 号：R730.3[医药卫生—肿瘤]