GC-MS验证筋伤止痛贴制备工艺  

Application of GC-MS in the verification of the preparing technology of Jinshangzhitong plaster

作　　者：秦文杰[1] 刘杰[2] 马开[2] 高寒[2] 王钢力[3] 林瑞超[3] 

机构地区：[1]北京中医药大学,北京100102 [2]河南省中医药研究院,郑州450004 [3]中国药品生物制品检定所,北京100050

出　　处：《药物分析杂志》2007年第5期714-717,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:通过考察各单味药材挥发性成分在成品中的转移率,确定制备工艺的可行性。方法:采用水蒸气蒸馏法分别从当归、乳香、没药、筋伤止痛贴中提取挥发油;用气相色谱-质谱法对其化学成分进行鉴定,同时用峰面积归一化法测定样品中各组分的质量分数,并考察各单味药材在成品中的转移率。结果:当归成分的转移率为75%,乳香成分的转移率为61.5%,没药成分的转移率为55.6%。结论:药材中的大部分挥发性成分在成品中均能检出,制备工艺合理可行。Objective：To verify the feasibility of the preparing technology of Jinshangzhitong plaster by estimating the transference rate of the volatile components of the crude drugs. Method：The volatile oils were extracted from Jinshangzhitong plaster, Radix Angelicae Sinensis, Olibanum and Myrrha by steam distillation and identified by GC - MS. The components were quantified with area normalization method. Their transference rate were caculated. Results：The transference rate of Radix Angelicae Sinensis,Olibanum, Myrrha were 75% ,61.5% ,55.6% respectively. Conclusion： Most of the volatile components of the crude drugs can be detected in the preparation, thus the preparing technology is resonable and feasible.

关 键 词：筋伤止痛贴 当归 乳香 没药 挥发油 气相色谱-质谱 

分 类 号：R917[医药卫生—药物分析学]