正常人脑颞叶白质内神经元数目的定量及分布情况  

Quantification and distribution of white matter neurons in the temporal lobe of normal individuals

作　　者：付永娟[1] 朴月善[1] 陈莉[1] 隗立峰[1] 卢德宏[1] 

机构地区：[1]首都医科大学北京宣武医院病理科,100053

出　　处：《中华神经科杂志》2007年第5期322-325,共4页Chinese Journal of Neurology

基　　金：北京市科技新星计划资助项目(2006863);北京市优秀人才培养专项基金(20042D-0501810);北京市留学人员科技活动启动项目资助项目

摘　　要：目的测定正常人脑颞叶白质内神经元数目及分布情况。方法将14例无神经系统疾病的中国人尸检脑标本经外侧膝状体平面的颞叶脑组织制成大切片,采用二维细胞计数方法,测定白质内神经元的密度、单位面积内神经元与胶质细胞总数、神经元占细胞总数的百分比以及神经元细胞核最大直径,并对神经元在白质内的分布情况进行研究。结果正常人脑颞叶白质内神经元密度的平均水平由浅至深依次为29.26、7.32和0个/mm^2。另外,正常人脑颞叶白质单位面积内神经元与胶质细胞总数、神经元占细胞总数的百分比以及神经元细胞核最大直径均随白质深度的增加而减少。结论正常人脑颞叶白质内存在神经元,神经元分布情况与白质深度有关。Objective To quantify the neurons in the temporal lobe white matter and find their distribution in the neurologically normal individuals. Methods The temporal lobe at the level of exterior genieulata body from brain autopsy samples of 14 neurologically normal individuals were made into large slice followed by quantitative analysis of neuron density, cell density, ratio and diameter of the neuronal nuclear and the distribution of white matter neurons using two-dimensional cell counting methods. Results With the depth of the white matter of the temporal lobe increasing, the neuron density decreased from 29. 26 neurons/ mm^2 to 7. 32 neurons/mm^2 and 0. 00 neurons/mm^2 , respectively; the cell density, neuron ratio and diameter of the neuronal nuclei all decreased. Conclusion There are neurons in the temporal lobe white matter of neurologically normal individuals, whose distribution of neurons is related to the depth of white matter.

关 键 词：颞叶 神经元 神经胶质 细胞计数 

分 类 号：R742.1[医药卫生—神经病学与精神病学]