髓母细胞瘤的临床因素与预后的相关性分析  

Correlation between the prognosis of medulloblastoma and relevant clinical factors:analysis of 73 cases

作　　者：杨柳松[1] 王宇倩[1] 黄峰平[1] 

机构地区：[1]复旦大学附属华山医院神经外科,上海200040

出　　处：《中华医学杂志》2007年第19期1322-1325,共4页National Medical Journal of China

摘　　要：目的探讨髓母细胞瘤临床与预后的相关因素。方法回顾性分析经手术后病理学证实的73例髓母细胞瘤患者的肿瘤部位、肿瘤切除率、脑干侵袭程度、放疗、化疗、分流手术、胶质分化等相关因素对其预后的影响。73例患者中男48例,女25例,年龄平均13.6岁。并对55例患者进行了随访。结果在获取随访的55例患者中手术死亡6例,余49例平均生存时间为61个月,术后3年仍存活者20例,3年生存率为63.98%;术后5年仍存活者8例,5年生存率为43%,全脑-后颅-脊髓放疗患者较仅做全脑一后颅放疗的患者预后好。结论髓母细胞瘤患者的预后日前仍较差,手术切除后正规放疗及化疗有助于提高预后。Objective To analyze the correlation between the prognosis of medulloblastoma （MB） and relevant clinical factors. Methods Seventy-three MB patients, 48 males and 25 females, aged 13.6 （2 ～40）, underwent surgical treatment and part of them underwent radiotherapy and/or chemotherapy. Follow-up was conducted among 55 cases for 40. 0 months （ 2 months ～ 8 years and 5 months）. The correlation between the prognosis and the clinical factors, such and sex, age, tumor location, extent of tumor resection, brainstem invasion, radiotherapy, chemotherapy, ventriculoperitoneal shunt and glial differentiation was analyzed. Results Six patients died postoperatively, and average survival time of the other 49 patients was 61 months. Twenty patients had a survival time of 3 years after operation, and the 3-year survival rate was 63. 98% ; and 8 patients survived for 5 years after operation with a 5-year survival rate of 43%. The prognosis Analysis showed that only radiotherapy was the only influencing factor of survival time. Those undergoing whole brain/posterior fossa plus spinal axis radiotherapy showed a better prognosis than those undergoing whole brain/posterior fossa radiotherapy. Conclusion The prognosis of MB is not good; yet, surgical resection with regular radiotherapy and chemotherapy is helpful for the prognosis of MB.

关 键 词：髓母细胞瘤 治疗 预后 相关性 

分 类 号：R739.4[医药卫生—肿瘤]