心理干预减轻含大剂量顺铂化疗致恶心呕吐反应的临床效果分析  

Clinical efficacy of psychological intervention with combined antiemetic regimen in treatment of nausea and vomiting induced by high-dose cisplatin based-chemotherapy

作　　者：苏梓航[1] 叶穗晖[1] 陈伟光[1] 杨正心[1] 

机构地区：[1]广州市红十字会医院南大学医学院第四附属医院胸外科,广州510220

出　　处：《中国肿瘤临床与康复》2007年第2期183-185,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的研究心理干预减轻含大剂量顺铂化疗致恶心呕吐的临床效果。方法103例恶性肿瘤患者接受含大剂量顺铂（70—120mg／m^2）化疗，随机抽取50例单纯应用药物进行镇吐治疗，另53例在药物镇吐基础上配合心理干预，比较两组的止吐效果。结果单纯药物组抗肿瘤药物致恶心呕吐反应Ⅰ度（含Ⅰ度）以下（WHO标准）发生率为20．0％，Ⅱ度发生率为8.0％，配合心理干预组恶心呕吐反应Ⅰ度（含Ⅰ度）以下发生率为9．0％，Ⅱ度发生率为4.0％（P〈0.005）。结论心理干预联合药物镇吐是防治含大剂量顺铂化疗致恶心呕吐的理想方法。Objective To study the antiemetic efficacy of psychological intervention in patients receiving high-dosage cisplatin-based chemotherapy. Methods Of 103 patients with malignancies treated with high-dosage cisplatin-based chemotherapy （70-120 mg/m^2） ,50 were chosen randomly to receive the anti emetic drugs only. The therapy with combination of antiemetic drugs and psychological intervention was adopted in the other 53 cases. The antiemetic efficacy of this two groups was compared. Results In the 50 cases treated with drugs only,the incidence of emetic reaction below grade- Ⅰ （WHO standard）and that grade-Ⅱ were 20.0% and 8.0% respectively,while those were 9.0% and 4.0% respectively in the 53 cases receiving combination therapy. There was statistically significant difference （ P 〈 0. 005 ）. Conclusion Combination of psychological intervention with antiemetic drugs can be used as an ideal antiemetic treatment in patients receiving high-dosage cisplatin-based regimen.

关 键 词：化学疗法 心理干预 药物镇吐 恶心呕吐 

分 类 号：R730.5[医药卫生—肿瘤]