单次与多次分割照射治疗转移性骨痛患者48例对照研究  

Comparison of Single and Multifraction Radiotherapy Schedules in the Treatment of Painful Bony Metastases

作　　者：胡国清[1] 胡长耀[1] 

机构地区：[1]同济医科大学附属同济医院肿瘤科,武汉430030

出　　处：《同济医科大学学报》1997年第1期50-52,共3页Acta Universitatis Medicinae Tongji

摘　　要：1994年1月至1995年10月共放射治疗转移性骨痛患者48例。非随机分为2组:单次照射组（A组）与多次分割组（B组）.两组临床资料基本相同，疗效相似，总的有效率A组84.0％（21／25），B组86.9％（20／23）。完全缓解率两组分别为48.0％（12／25）和56.5％（13／23）（P＞0.05）.显效时间A组明显短于B组，48h内显效者两组分别占72.0％和43.5％（P＜0.05）。初步研究结果显示，放疗是治疗骨转移疼痛的有效方法，止痛作用迅速。单次与多次分割照射可获得相同效果。From January 1994 to October 1995, 48 patients with painful bony metastases were treated by radiotherapy. They were entered into one of two dose-fractionation schedules: 25 patients with a single treatment of 800 c Gy (group A), 23 patients with a dose of 2 800-3000 cGy in 8-10 fractions (group B). Pain relief was 84.0 % (21/25) in group A and 86. 9 % (20/23) in group B. Complete relief rate were 48. 0 % (12/25) and 56. 5 % (13/23), respectively (P＞0.05). The onset of pain relief occurs earlier in group A than in group B. The patients achieving pain relief within 48 hours,was 72. 0 % (18/25) in group A and 43. 5 % (10/23) in group B (P＜0.05). The results demonstrate that local radiotherapy is a very rapid and effective Palliative treatment for painful bony metastases.

关 键 词：肿瘤转移 疼痛 骨肿瘤 放射疗法 

分 类 号：R738.105[医药卫生—肿瘤] R730.55[医药卫生—临床医学]