^(18)氟-脱氧葡萄糖PET/CT显像在原发性肝细胞癌中的应用研究  

The Diagnostic Performance of ^(18)FDG PET/CT in Hepatocelluar Carcinoma

作　　者：胡裕效[1] 朱虹[1] 张宗军[2] 常林凤[1] 吴江[1] 王新刚[1] 黄红丽[1] 卢光明[2] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院核医学科,南京210002 [2]南京大学医学院临床学院南京军区南京总医院医学影像科,南京210002

出　　处：《中国医学影像学杂志》2007年第3期182-185,共4页Chinese Journal of Medical Imaging

摘　　要：目的:评价18氟-脱氧葡萄糖(18FDG)PET/CT在原发性肝细胞癌中的应用价值。材料和方法:28例患者被分成3组。第一组为未经相关治疗的HCC组,共13例;第二组为肝脏良性病变组,共9例;第三组为HCC治疗后疗效观察组,共6例。18FDGPET/CT影像学表现结合手术病理及临床随访,计算18FDGPET/CT对HCC诊断的敏感性,并分析标准摄取值(suv)的影响因素。结果:第一组患者Ⅰ型表现7例,Ⅱ型表现5例,Ⅲ型表现1例;第二组患者Ⅰ型表现0例,Ⅱ型表现4例,Ⅲ型表现5例;18FDGPET/CT对HCC诊断的灵敏度为:53.8%,其suv值的大小和肿瘤的生物学行为有关。第三组患者Ⅰ型表现5例,Ⅱ型表现0例,Ⅲ型表现1例,其suv值的大小与肿瘤残留有关。结论:18FDGPET/CT显像在HCC生物学特性评估及HCC治疗后疗效监测方面有明显优势。Purpose： Hepatocellular carcinoma （HCC） is one of the most common malignancies in China, but its ^18F-FDG-PET diagnosis was reported far from satisfactory. The aim of this study was to evaluate the value of ^18F-2-fluoro-2-deoxy-D-glucose（^18FDG） PET/CT in patients with HCC. Materials and Methods： 28 patients were divided into 3 groups. In Group 1, 13 HCCs had not received any treatment before; In Group 2, 9 cases were confirmed to have benign liver tumors. The remaining 6 patients （ Group 3 ） were coming for follow-up post therapy for their HCCs. Images were compared with the histopathologic findings at surgery or with clinical follow-up findings. The sensitivity of ^18FDG PET/CT was calculated and the influencing factors of standardized uptake value （suv） were analyzed. Results： The ^18FDG PET/ CT findings in Group 1 showed 7 ＇ hot＇ lesions in liver, （Type Ⅰ ）, 4 and 1 of equal or less uptake than surrounding liver tissue（ Type Ⅱ and Type Ⅲ ）, respectively. None in Group 2 showed Type Ⅰ uptake, but 4 Type Ⅱ and 5 Type Ⅲ, respectively. The sensitivity of ^18FDG PET/ CT diagnosis of HCC was 53.8%. The SUV had the relationship with the biological properties of HCCs. Five HCCs in Group 3 had Type Ⅰ uptake, the remaining one had Type Ⅲ uptakes. The SUV related with the tumor residue. Conclusion： ^18FDG PET/CT had obvious advantages in evaluating the biological properties of HCCs and in monitoring the response after therapy.

关 键 词：原发性肝细胞癌 ^18氟-脱氧葡萄糖 PET/CT 

分 类 号：R730.44[医药卫生—肿瘤]