PTEN、P16表达与原发性胆囊癌病理生物学行为及预后的关系  

Significance of PTEN and P16 protein expression in primary gallbladder carcinoma

作　　者：许元鸿[1] 欧阳兵[1] 于国志[1] 郭仁宣[1] 郭克建[1] 

机构地区：[1]中国医科大学附属第一医院普通外科,辽宁省沈阳市110001

出　　处：《世界华人消化杂志》2007年第11期1314-1317,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨PTEN、P16在原发性胆囊癌中的表达与其病理生物学行为和预后的关系.方法:采用免疫组化CSA法对56例胆囊癌进行PTEN和P16蛋白的定位观察.结果:PTEN、P16在原发性胆囊癌中阳性表达率为46.4%,42.9%,显著低于胆囊良性病变(92.3%,76.9%;P<0.05).PTEN、P16表达与胆囊癌的组织类型、病理学分级无相关(P>0.05),与胆囊癌的浸润、转移和预后明显相关(P<0.05),PTEN和P16基因蛋白表达存在着明显的正相关(r=0.8746,P<0.05).结论:PTEN和P16基因蛋白低表达可能是胆囊癌发生、发展中的分子事件,PTEN、P16表达可作为评估胆囊癌病理生物学行为及预后的参考指标.AIM： To investigate the expression of PTEN and P16 protein expression as well as their correlations with the pathobiological behaviors and prognosis of PGC. METHODS： The protein expression of PTEN and P16 were observed in 56 cases of PGC and 26 cases of gallbladder benign lesions were observed by imrnunohistochemistry （CAS method）. RESULTS： The positive rates of PTEN and P16 expression in PGC were 46,4% and 42.9%, respectively, significantly lower than those in gallbladder benign lesions （92.3%, 76.9%; P 〈 0.05）. PTEN and P16 expression were associated with the invasion, metastasis and prognosis （P 〈 0.05）, but not with the histological types and grades. There existed positive correlation between PTEN and P16 expression in PGC （r = 0.8746, P 〈 0.05）. CONCLUSION： Down-regulated PTEN and P16 expression are involved in the occurrence and development of PGC, which may be useful in evaluating the pathobiological characteristics and prognosis of PGC.

关 键 词：胆囊肿瘤 PTEN蛋白 P16蛋白 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]