MTA1蛋白在乳腺癌中的表达及临床意义  

Expression of MTA1 pretein in breast cancer and its significance

作　　者：李孟圈[1] 李靖若[1] 鲍俊涛[1] 苏静[1] 李建章[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《山东医药》2007年第15期17-19,共3页Shandong Medical Journal

基　　金：河南省医学高新技术发展扶持项目(20060038)

摘　　要：目的探讨肿瘤转移相关基因1(M TA 1)蛋白表达与乳腺癌生物学行为之间的关系。方法应用免疫组化SP法检测56例乳腺癌组织中M TA 1蛋白及雌激素受体(ER)的表达。结果56例乳腺癌组织中39例M TA 1蛋白阳性表达,阳性率为69.6%(39/56)。M TA 1高表达与乳腺癌组织学分级、临床分期和淋巴结转移有关(P<0.05),与年龄和ER状况无关(P>0.05)。结论M TA 1蛋白可作为诊断乳腺癌转移复发的参考指标,并有望成为乳腺癌基因治疗的新靶点。[Objective] To investigate the relationship between MTA1 gene expression and biological behavior of human breast cancer. [Methods] SP immunohistochemical technique was used to detect the expression of MTAI protein and estrogen receptor（ER） of 56 human breast cancer samples. [Results] The positive rates of MTA1 protein was 69.6%（39/56）.The over-expression of MTA1 protein was significantly related with differentiation degree ,clinical stage and lymph node metastasis（ P 〈 0.05） ,and was not related with age and ER （P 〈 0. 05）. [Conclusion] MTA1 can be used marker for evaluation of tumor malignancy, judgment of recurrence and metastasis in patients with breast cancer. MTA1 has promise of becoming a novel target for brest cancer gene therapy.

关 键 词：乳腺癌 肿瘤转移相关基因蛋白 

分 类 号：R737.9[医药卫生—肿瘤]