Synthesis and Bio-activities of Pyrazolyl or Pyridinyl Substituted Tonghaosu Analogs  

作　　者：尹标林 陈立 徐汉虹 张健存 吴毓林 

机构地区：[1]Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, Guangong 510663, China [2]State Key Laboratory ofBio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [3]Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou, Guangdong 510642, China

出　　处：《Chinese Journal of Chemistry》2007年第6期808-813,共6页中国化学（英文版）

摘　　要：11 pyrazolyl or pyridinyl substituted tonghaosu analogs were synthesized. Structures of all the new compounds were confirmed by ^1H NMR, IR, MS, HREIMS or elemental analysis. Their antifeedant activity against larvae of large white butterfly （Pieris brassicae L.）, larvicidal activity toward mosquito （Culex quinquefasciatus Say） and growth control activity toward larvae of Spodoptera litura Fab were examined. Some of them exhibited antifeeding activities comparable to or stronger than tonghaosu Z-1. Based on the activity data, the preliminary structure-activity relationship was also discussed, which might be instructive for finding out lead compounds with better bioactivities in the future.11 pyrazolyl or pyridinyl substituted tonghaosu analogs were synthesized. Structures of all the new compounds were confirmed by ^1H NMR, IR, MS, HREIMS or elemental analysis. Their antifeedant activity against larvae of large white butterfly （Pieris brassicae L.）, larvicidal activity toward mosquito （Culex quinquefasciatus Say） and growth control activity toward larvae of Spodoptera litura Fab were examined. Some of them exhibited antifeeding activities comparable to or stronger than tonghaosu Z-1. Based on the activity data, the preliminary structure-activity relationship was also discussed, which might be instructive for finding out lead compounds with better bioactivities in the future.

关 键 词：SPIROKETAL tonghaosu analog ANTIFEEDANT LARVICIDAL growth control Pieris brassicae Culex quinquefasciatus Spodoptera litura 

分 类 号：TQ453.4[化学工程—农药化工]