This work was financially supported by the National Natural Science Foundation of China(No.81903494);the Scientific Research Foun-dation of Qingdao University.
Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse fam-ily of polycyclic polyphenols.Some of them are consequently suggested as lead structures for drug developm...
supported by the Beijing Natural Science Foundation(No.7194299);Fundamental Research Funds for the Central Universities(No.3332018089);the CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-010);the Drug Innovation Major Project(No.2018ZX09711001-002-010,2018ZX09735006)。
Three novel polycyclic polyprenyled acylphloroglucinols,Hyperscabins A-C,were obtained from the aerial parts of Hypericum scabrum.They featured an unprecedented 5,5-spiro ketal subunit with the loss of C-2’carbonyl i...
The spiro concept for chiral ligand design represents an important contribution to the area of asymmetric catalysis. Due to the considerable difficulties in the construction of enantiopure all-carbon spiro backbones, ...
support from the Natural Science Foundation of China(Nos.29070070,29372077).
A reaction between steroidal sapogenins and hydrogen sulfide promoted by BF3•Et2O is described.The thio-diosgenin and thiotigogenin comprising a sulfur atom on the F ring can be easily afforded in one step under this ...
the“Hundred Talents Project”of Chinese Academy of Science and“High-end Science and Technology Talents Program”’of Yunnan Province(2011HA008)。
The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between p...
Organic microporous materials based on spiroketal and spirothioketal polymers were synthesized through 1,3- dioxol-forming polymerization reaction between pentaerythritol or pentaerythritol tetrathiol and different ty...
11 pyrazolyl or pyridinyl substituted tonghaosu analogs were synthesized. Structures of all the new compounds were confirmed by ^1H NMR, IR, MS, HREIMS or elemental analysis. Their antifeedant activity against larvae ...
Project supported by the National Natural Science Foundation of China (Nos. 29672083, 20072043), the Chinese Academy of Sciences, the Ministry of Science and Technology of China (No. G2000077502), and the Shanghai Commission of Science and Technology.
Twenty-one tonghaosu analogs were synthesized via hydroamination or selective reduction of the endocyclic double bond of the corresponding dienol spiroketals. Structures of all the new compounds were confirmed by ^1H ...
the National Natural Science Foundation of China (Nos. 29672083, 20072043), the Chinese Academy of Sciences, the State Ministry of Science and Technology (No. 2000077502), the Shanghai Committee of Science and Technology.
A new series of phenoxy-phenyl moieties containing tonghaosu analogs with varied B-ring 9 were synthesized and characterized by spectral studies. Their insect antifeedant activity against Pieris brassicae and insectic...
the National Natural Science Foundation of China (Grant Nos. 29672083, 20072043), Chinese Academy of Sciences, the State Ministry of Science and Technology (No. G2000077502), Shanghai Committee of Science and Technology and the
The methanolic extract from a Chinese endemic Chrysanthemum plant, Dendranthema indicum var. aromaticum, was found to show high antifeeding activity against Pieris brassicae L., and by bioassay-guided separation, the ...