Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes  

作　　者：Ping Lin Xue Li Yuchen Xin Hongying Li Gang Li Hongxiang Lou 

机构地区：[1]Department of Natural Medicinal Chemistry and Pharmacognosy,School of Pharmacy,Qingdao University,Qingdao 266071,China [2]Department of Natural Product Chemistry,Key Laboratory of Chemical Biology of Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China

出　　处：《Engineering Microbiology》2022年第3期37-46,共10页工程微生物学（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.81903494);the Scientific Research Foun-dation of Qingdao University.

摘　　要：Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse fam-ily of polycyclic polyphenols.Some of them are consequently suggested as lead structures for drug development.Among them,rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannu-lated[5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit.This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities,includ-ing antimicrobial,anticancer,and enzyme inhibition activity.The unique structures,intriguing biosynthesis,and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists.This review covers the isolation,characterization,biosynthesis,and biological studies of these structurally diverse and complex rubromycins.

关 键 词：Natural products Rubromycins SPIROKETAL BIOSYNTHESIS Bioactivity 

分 类 号：O64[理学—物理化学]