口腔扁平苔藓中人乳头瘤病毒的检测  

Detection of HPV in oral lichen planus

作　　者：雷蕾[1] 李辉■ 孙瑜[3] 

机构地区：[1]暨南大学医学院口腔系,广州510632 [2]湖北医科大学 [3]湖北医科大学病毒研究所

出　　处：《临床口腔医学杂志》1997年第1期5-7,共3页Journal of Clinical Stomatology

摘　　要：为研究口腔扁平苔藓（OLP）与人乳头瘤病毒（HPV）的关系．作者采用聚合酶链（PCR）技术，对22例OLP中的HPV低危型──11型以及高危型—16型DNA分别进行了检测，并以10例正常口腔粘膜（NOM）作为对照。结果表明：PCR是检测OLP中HPV较为理想的方法。OLP中的HPV与NOM相比较，11型相对升高。OLP各临床分型中，网纹型的HPV阳性百分比最高，该型的病程迁延．治疗后易复发，可能与HPV的潜伏和感染有关，4例糜烂型，即有2例含有HPV16，提示糜烂型与癌变的关系。HPV在NOM中的存在。表明HPV可以无症状或以潜伏的形式存在于口腔粘膜。For exploring the relationship between human Papilloma viruses(HPV) and oral lichen planus (OLP),polymerase chain reaction were used to detect HPV low rish type-- 11 type and high risk type--16 type in OLP,and control with oral normal mucosa(NOM). The study suggest: PCR is a method more ideal than others about detection HPV in OLP. Compared with HPV in NOM,HPV11 type in OLP was more,whether if suggest that low risk type may play a role in OLP. HPV percentage in reticular lesion is biger than other type lesions. Reticular lesion can be duration for a long time. and easy recurrence after therapy.may be this is because of latency or infection of virus. In four erosive lesions, two ones have HPV16,it perhaps hint the relation between erosiue lesion and malignant transformation. And last,which present HPV in NOM,led to speculations that HPV could persist in oral tissue as an asymptomatic or latent form.

关 键 词：口腔扁平苔藓 人乳头瘤病毒 聚合酶链反应 

分 类 号：R781.502[医药卫生—口腔医学]