移位修正JPSTH算法的归一化修正  

An improved approach of shift-corrected joint peristimulus time histogram

作　　者：黄丹[1] 刘谦[1] 李艳玲[1] 陈琳[1] 林云生[1] 曾绍群[1] 

机构地区：[1]华中科技大学生物医学光子学教育部重点实验室-武汉光电国家实验室(筹)生物医学光子学研究部,武汉430074

出　　处：《北京生物医学工程》2007年第3期285-288,共4页Beijing Biomedical Engineering

基　　金：国家自然科学基金(30328014);教育部科学技术研究重大项目(重大10420)资助

摘　　要：针对移位修正联合刺激后时间直方图的处理结果依赖于具体实验数据的不足,本文提出了一种改进算法,对移位修正联合刺激后时间直方图进行归一化处理。将该方法应用于多电极阵列细胞外记录的海马神经元网络电刺激后的响应信号的分析,结果表明,该方法在神经元网络连接状态不变而具体实验数据不同的情况下,能准确体现神经元网络的连接状态。While using the shift-corrected JPSTH analyze data, the result depends on the details of the experiment data. To solve the problem, an improved method was proposed by normalizing the shift-corrected JPSTH. The proposed method was been applied to analyze the multi-channel extracellular recording of the hippocampal neuronal network. The result shows that, when the neuronal network keeps a constant connection state but has experiment data with different details, the proposed method can embody exactly the connection state of the neuronal network.

关 键 词：海马神经元网络 联合刺激后时间直方图 移位修正 归一化 多电极阵列 

分 类 号：R318.04[医药卫生—生物医学工程]