Verifying the hypothesis of disconnection syndrome in patients with conduction aphasia using diffusion tensor imaging  

作　　者：Yanqin Guo Jing Xu Yindong Yang 

机构地区：[1]Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College, Mudanjiang 157011, Heilongjiang Province, China

出　　处：《Neural Regeneration Research》2007年第4期217-220,共4页中国神经再生研究（英文版）

摘　　要：BACKGROUND： It is thought in disconnection theory that connection of anterior and posterior language function areas, i.e. the lesion of arcuate fasciculus causes conduction aphasia. OBJECTIVE： To verify the theory of disconnection elicited by repetition disorder in patients with conduction aphasia by comparing the characteristics of diffusion tensor imaging between healthy persons and patients with conduction aphasia. DESIGN： Case-control observation. SETTING： Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College. PARTICIPANTS： Five male patients with cerebral infarction-involved arcuate fasciculus conduction aphasia, averaged （43±2） years, who hospitalized in the Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College from February 2004 to February 2005 were involved in this experiment. The involved patients were all confirmed as cerebral infarction by skull CT and MRI, and met the diagnosis criteria revised in 1995 4^th Cerebrovascular Conference. They were examined by the method of Aphasia Battery of Chinese （ABC） edited by Surong Gao. The results were poorer than auditory comprehension disproportionately, and consistented with the mode of conduction aphasia. Another 5 male healthy persons, averaged （43 ± 1 ） years, who were physicians receiving further training in the Department of Neurology, Beijing Tiantan Hospital were also involved in this experiment. Informed consents of detected items were obtained from all the subjects. METHODS： All the subjects were performed handedness assessment with assessment criteria of handedness formulated by Department of Neurology, First Hospital Affiliated to Beijing Medical University. Arcuate fasciculus of involved patients and health controls were analyzed with diffusion tensor imaging （DTI） and divided into 3 parts （anterior, middle and posterior segments） for determining FA value （mean value was obtained after three times of measurements）, and a comparison of FA value was made beBACKGROUND： It is thought in disconnection theory that connection of anterior and posterior language function areas, i.e. the lesion of arcuate fasciculus causes conduction aphasia. OBJECTIVE： To verify the theory of disconnection elicited by repetition disorder in patients with conduction aphasia by comparing the characteristics of diffusion tensor imaging between healthy persons and patients with conduction aphasia. DESIGN： Case-control observation. SETTING： Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College. PARTICIPANTS： Five male patients with cerebral infarction-involved arcuate fasciculus conduction aphasia, averaged （43±2） years, who hospitalized in the Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College from February 2004 to February 2005 were involved in this experiment. The involved patients were all confirmed as cerebral infarction by skull CT and MRI, and met the diagnosis criteria revised in 1995 4^th Cerebrovascular Conference. They were examined by the method of Aphasia Battery of Chinese （ABC） edited by Surong Gao. The results were poorer than auditory comprehension disproportionately, and consistented with the mode of conduction aphasia. Another 5 male healthy persons, averaged （43 ± 1 ） years, who were physicians receiving further training in the Department of Neurology, Beijing Tiantan Hospital were also involved in this experiment. Informed consents of detected items were obtained from all the subjects. METHODS： All the subjects were performed handedness assessment with assessment criteria of handedness formulated by Department of Neurology, First Hospital Affiliated to Beijing Medical University. Arcuate fasciculus of involved patients and health controls were analyzed with diffusion tensor imaging （DTI） and divided into 3 parts （anterior, middle and posterior segments） for determining FA value （mean value was obtained after three times of measurements）, and a comparison of FA value was made be

关 键 词：aphasia  conduction diffusion magnetic resonance imaging 

分 类 号：R741.04[医药卫生—神经病学与精神病学] R767.64[医药卫生—临床医学]