Effect of topiramate and traditional antiepileptic drugs on pituitary-sexual gland axis in adult males with epilepsy  

作　　者：Fei Xu Liang Yu Jie Liu Yongjie Luo Hongbin Sun 

机构地区：[1]Departmetn of Neurology, Sichuan Provincial People＇s Hospital, Sichuan Academy of Medical Science, Chengdu 610072, Sichuan Province, China

出　　处：《Neural Regeneration Research》2007年第4期244-247,共4页中国神经再生研究（英文版）

摘　　要：BACKGROUND： Some reports indicate that traditional antiepileptic drugs can cause a certain effect on reproductive endocrine system in epileptic patients. However, the effect of topiramate on reproductive endocrine system needs to be further studied. OBJECTIVE： To compare the effects of topiramate and traditional valproic acid and carbamazepine on pituitary-sexual gland axis in adult males with epilepsy. DESIGN： Self-contrast and randomly parallel controlled study. SETTING： Sichuan Academy of Medical Sciences （Department of Neurology, Sichuan Provincial People＇s Hospital）. PARTICIPANTS： A total of 54 male epileptic patients aged from 18 to 75 years were selected from Department of Neurology, Sichuan Provincial People＇s Hospital from January 2004 to June 2006. All patients were diagnosed as epilepsy based on illness history and electroencephalogram （EEG）, and types of epilepsy were classified based on the theory of epilepsy and epilepsy syndrome established by International Anti-epilepsy League in 1989 and 2001. The accepted patients and their relatives provided the confirmed consent. METHODS： ① The accepted patients were randomly divided into traditional treatment group [n =26, mean age of （34 ± 14） years] and topiramate group [n =28, mean age of （28 ± 17） years]. In addition, based on various kinds of drugs, patients in the traditional treatment group were divided into two subgroups, including carbamazepine group （n =14） and valproic acid group （n =12）. Patients in both subgroups were respectively treated with carbamazepine （100 mg/table, Shanghai Sanwei Pharmaceutical Factory, batch number： 060705） and valproic acid （200 mg/table, Hunan Xiangzhong Pharmaceutical Co., Ltd., batch number： 061128）. Patients in topiramate group were treated with topiramate （25 mg/table, Xi＇an Yangsen Pharmaceutical Co., Ltd., batch number： 060215836）. Administration： The beginning dosage of topiramate was 25 mg/d, and then increased 25 mg/d per week. The final dosage BACKGROUND： Some reports indicate that traditional antiepileptic drugs can cause a certain effect on reproductive endocrine system in epileptic patients. However, the effect of topiramate on reproductive endocrine system needs to be further studied. OBJECTIVE： To compare the effects of topiramate and traditional valproic acid and carbamazepine on pituitary-sexual gland axis in adult males with epilepsy. DESIGN： Self-contrast and randomly parallel controlled study. SETTING： Sichuan Academy of Medical Sciences （Department of Neurology, Sichuan Provincial People＇s Hospital）. PARTICIPANTS： A total of 54 male epileptic patients aged from 18 to 75 years were selected from Department of Neurology, Sichuan Provincial People＇s Hospital from January 2004 to June 2006. All patients were diagnosed as epilepsy based on illness history and electroencephalogram （EEG）, and types of epilepsy were classified based on the theory of epilepsy and epilepsy syndrome established by International Anti-epilepsy League in 1989 and 2001. The accepted patients and their relatives provided the confirmed consent. METHODS： ① The accepted patients were randomly divided into traditional treatment group [n =26, mean age of （34 ± 14） years] and topiramate group [n =28, mean age of （28 ± 17） years]. In addition, based on various kinds of drugs, patients in the traditional treatment group were divided into two subgroups, including carbamazepine group （n =14） and valproic acid group （n =12）. Patients in both subgroups were respectively treated with carbamazepine （100 mg/table, Shanghai Sanwei Pharmaceutical Factory, batch number： 060705） and valproic acid （200 mg/table, Hunan Xiangzhong Pharmaceutical Co., Ltd., batch number： 061128）. Patients in topiramate group were treated with topiramate （25 mg/table, Xi＇an Yangsen Pharmaceutical Co., Ltd., batch number： 060215836）. Administration： The beginning dosage of topiramate was 25 mg/d, and then increased 25 mg/d per week. The final dosage

关 键 词：CARBAMAZEPINE valproic acid sex hormones PROLACTIN 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]