血清p53抗体在肺癌早期诊断中的价值  

Value of serological p53 antibody for early diagnosis of lung cancer

作　　者：张东明 杨德昌[2] 

机构地区：[1]平凉市第二人民医院呼吸科,744000 [2]西安交通大学医学院第二附属医院呼吸科,710004

出　　处：《国际呼吸杂志》2007年第10期734-736,共3页International Journal of Respiration

摘　　要：目的探讨p53抗体在肺癌诊断,尤其是早期诊断中的价值。方法应用酶联免疫吸附法（enzyme linked immunosorbent assay,ELISA）检测32例健康者、37例肺疾病患者和82例肺癌患者血清中p53抗体的水平。结果肺癌患者血清p53抗体水平显著高于肺疾病及健康者（P〈0.05）;血清p53抗体诊断肺癌的敏感性和特异性分别为29.27%及100%;血清p53抗体阳性率与肺癌病理分型及临床分期无关（P〉0.05）。结论p53抗体可作为肺癌诊断,尤其是早期诊断的新的有价值的标志物。Objective To explore the diagnosis value of serum p53 antibody in lung cancer,especially in early lung cancer. Methods Serum p53 antibody levels were detected by enzyme linked immunosorbent assay（ELISA） in 32 cases of healthy persons,37 cases of lung diseases patients and 82 cases of lung cancer respectively. Results The level of serum p53 antibody was significantly higher in lung cancer sufferers than in benign lung disease sufferers and healthy persons （ P 〈0.05）. The sensitivity and specificity of serum p53 antibody in diagnosing lung cancer were 29.27% and 100% respectively. The positive rate of serum p53 antibody had no relationship with the pathology type and clinical stage of lung cancer （P 〉 0.05）. Conclusions The serum p53 antibody can be considered as a new valuable marker in diagnosing lung cancer, especially in early lung cancer.

关 键 词：肺癌 P53抗体 早期诊断 肿瘤标志物 

分 类 号：R734[医药卫生—肿瘤]