喉癌发生发展过程中TRAIL和Survivin蛋白的表达研究  

Expression of TRAIL and Survivin proteins in the carcinogenesis and development of laryngeal carcinoma

作　　者：吴凯[1] 马茂强[1] 王春海[1] 张勇[1] 

机构地区：[1]山东中医药大学附属医院病理科,山东济南250011

出　　处：《山东大学耳鼻喉眼学报》2007年第2期138-140,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的:探讨喉癌发生发展过程中TRAIL、Survivin蛋白的表达及与喉癌病理特征的关系。方法:采用免疫组化SP法对48例喉癌患者手术后大体标本中喉正常黏膜、不典型增生及浸润癌组织进行检测及分析。结果:TRAIL蛋白从正常黏膜-不典型增生-浸润癌呈渐进性低表达,而Survivin蛋白则呈渐进性高表达。喉浸润癌组织中TRAIL蛋白的低表达与Survivin蛋白的高表达呈负相关(r=-0.510,P<0.01)。结论:TRAIL和Survivin两种蛋白参与了喉癌的发生发展,两者的表达失调与喉癌发生密切相关。Objective： To explore the correlation between the expressions of TRAIL and Survivin proteins and the pathologic features of laryngeal epithelial lesions. Methods： Immunohistoehemistry was used to determine the expressions of TRAIL and Survivin proteins in normal mueosa and displasia and invasive carcinoma tissues of 48 eases of laryngeal carcinoma. Results： The expression of Survivin protein progressively increased, whereas that of TRAIL protein gradually decreased in a route of normal mueosa and displasia and invasive carcinoma tissues. The expression of TRAIL protein in laryngeal invasive carcinoma was negatively correlated with that of Survivin protein （ r = -0.510, P 〈 0.01）. Conclusions： The expressions of TRAIL and Survivin proteins are significantly related to the genesis and progression of laryngeal carcinoma.

关 键 词：喉肿瘤 病理学 免疫组织化学 肿瘤坏死因子相关的凋亡诱导配体 凋亡抑制基因 

分 类 号：R739.65[医药卫生—肿瘤]