合并海洋性贫血的尿毒症患者肾移植的临床观察  

Curative effectiveness of kidney transplantation performed on uremic patients complicated with thalassemia

作　　者：聂峰[1] 孙煦勇[1] 尹晓林[1] 赵月涛[1] 谭庆[1] 赖彦华[1] 董建辉[1] 谭刘欣[1] 

机构地区：[1]解放军第三○三医院器官移植中心,南宁530021

出　　处：《中华器官移植杂志》2007年第5期284-285,共2页Chinese Journal of Organ Transplantation

基　　金：广西壮族自治区卫生厅科研基金(Z2005175)

摘　　要：目的探讨海洋性贫血对尿毒症患者肾移植效果的影响。方法为46例合并海洋性贫血的尿毒症患者施行肾移植(海洋性贫血组),其中α海洋性贫血26例,β海洋性贫血20例,观察患者术后移植肾功能恢复延迟(DGF)和排斥反应的发生率以及贫血的纠正情况,对于移植肾功能恢复正常者,记录其肾功能恢复正常的时间,并测定血肌酐值。以同期施行的131例肾移植(均伴有程度不等的贫血,但非海洋性贫血)为对照。结果海洋性贫血组DGF的发生率为26.1%,对照组为23.7%,二者比较,差异无统计学意义。术后6个月,人、肾均存活,且未失访的患者,海洋性贫血组有39例,对照组有109例,6个月内,海洋性贫血组30.8%发生排斥反应,对照组32.1%发生排斥反应,两组比较,差异无统计学意义;海洋性贫血组的血肌酐值为(121±20)μmol/L,对照组为(128±33)μmol/L,两组比较,差异无统计学意义;海洋性贫血组79.5%的贫血得到纠正,对照组76.1%的贫血得到纠正,两组比较,差异无统计学意义。结论合并海洋性贫血的尿毒症患者可接受肾移植治疗,临床效果与不合并该病者相仿。Objective To observe the curative effectiveness of kidney transplantation on uremic patients complicated with Thalassemla. Methods Forty-six cases of uremic patients complicated with Thalassemia （26 cases of alpha-thalassemia,20 cases of beta-thalassemia） subject to kidney transplantation were retrospectively studied as the anemia group. Incidence of delayed graft function restoration, rejection （hyperacute rejection,accelerated rejection and acute rejection） and anemia correction were observed. Time needed for renal function restoration was recorded and creatinine value （Cr） was measured in those patients whose kidney function restored after kidney transplantation. Control group ineluded 131 cases of kidney transplantation performed concurrently that accompanied with different content of anemia other than thalassemia. Results Incidence of DGF was 26. 1% and 23.7% in thalassemia group and control group, respectively. Six months after transplantation, 39 cases in thalassemia group and 109 cases in control group with follow-up were host and kidney alive. In 6 months, rejection ratio was 30. 8% in thalassemia group and 32. 1% in control group respectively. Cr value was （121 ± 20） μmol/L and （ 128 ± 33） μmol/L in thalassemia group and control group, respectively. Ratio of anemia correction in thalassmia and control groups was 79. 5% and 76. 1%, respectively. No indexes above were found to be statically significantly different between these two groups. Conclusion Uremic patients complicated with thalassemia is suitable for kidney transplantation,with clinical effectiveness similar to those without thalassemia.

关 键 词：肾移植 地中海贫血 尿毒症 

分 类 号：R556[医药卫生—血液循环系统疾病] R699[医药卫生—内科学]