78例乳腺浸润性导管癌预后多因素分析  

The multivariable analysis of prognosis in 78 cases with invasive duct carcinomas of the breast

作　　者：丁锦辉[1] 于冰[1] 王闽全[1] 孙国辉[1] 

机构地区：[1]新疆医科大学第二附属医院肿瘤外科,新疆乌鲁木齐830028

出　　处：《新疆医科大学学报》2007年第4期390-392,共3页Journal of Xinjiang Medical University

摘　　要：目的:探讨乳腺浸润性导管癌临床病理指标与预后的关系。方法:对78例乳腺浸润性导管癌患者的临床和随访资料进行回顾性分析,应用Cox模型分析影响乳腺浸润性导管癌预后的临床病理指标。结果:乳腺浸润性导管癌以36～55岁多见,且以Ⅱ、Ⅲ期居多,预后较差,3年生存率和5年生存率分别为68.6%(35/51)和48.3%(14/29)。多因素Cox回归分析显示:患病年龄、TNM分期和组织学分级3项指标反映乳腺浸润性导管癌的预后情况,危险度分别为3.574、31.661、2.019。结论:判断乳腺浸润性导管癌的预后,要充分重视患病年龄、TNM分期和组织学分级临床病理指标。Objective： To explore the relation of the clinico-pathological markers and prognosis in breast invasive duct carcinomas. Methods： The clinical and follow-up data of 78 cases with breast invasive ductal carcinomas were summarized, Cox model were used to analyze the relationship between clinico-pathological markers and prognosis in invasive ductal carcinomas of the breast. Results： Age of patient with breas invasive ductal carcinomas were more than half between 36 and 55 years old and mainly belonged to Ⅱ , Ⅲ stage of TNM, prognosis was poorly. Seventy eight eases have followed up： there-year and five-year survival rates were 68. 6% （35/51） and 48. 3% （14/29）, respectively. Multivariable Cox regression analysis revealed that patient age, TNM stages and histological grade were three important and independent prognostic factors in invasive ductal carcinomas of breast, the hazard ratios were 3. 574, 31. 661, and 2. 019, respectively. Conclusions： The traditional clinico-pathological markers such as patient age, TNM stages and histological grade should be attach importance to the prognosis of invasive ductal carcinomas of breast.

关 键 词：乳腺肿瘤 浸润性导管癌 临床病理指标 COX模型 预后 

分 类 号：R737.9[医药卫生—肿瘤]