三氧化二砷在兔眼小梁切除术中应用的实验研究  

A Study on Applying Arsenic Trioxide in Trabeculectomy on Rabbit Eyes

作　　者：魏秀华[1] 冮林红[1] 庞艳梅[1] 刘平[2] 

机构地区：[1]哈尔滨医科大学第五临床医学院,黑龙江大庆163316 [2]哈尔滨医科大学第一临床医学院,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2007年第5期345-346,共2页Heilongjiang Medical Journal

摘　　要：目的观察不同浓度三氧化二砷(ATO)在兔眼小梁切除术中的抗瘢痕形成作用,明确其在抗青光眼手术中应用的安全浓度。方法随机选正常兔32只,64眼,分为4组,每组8只兔(16眼)均行小梁切除术,在术中用不同浓度三氧化二砷(10μmol/L,5.0μmol/L,0.5μmol/L)及生理盐水,术后7、30 d用裂隙灯观察滤过泡,角膜上皮,Perkin压平眼压计测量眼压,测量房水中的三氧化二砷的浓度。结果术后7 d及30 d眼压5.0μmol/L组低于生理盐水组(P<0.05);毒性反应:生理盐水组<0.5μmol/L<5.0μmol/L<10μmol/L。结论三氧化二砷可用在青光眼滤过术中抗瘢痕形成,且适宜浓度产生毒性微弱。Objective To study anfiscarring effects of Arsenic trioxide through applying different concentration Arsenic trioxide（ATO） during trabeculectomy on rabbit eyes. Methods All rabbits received trabeculectomy, and four groups differently applied Sodium Chloride, and three concentration Arsenic trioxide. We observed intraocular pressure of rabbits with Perkin tonometer and filtration bubble were observed with slit lamp on 7th and 30th postoperative day. Results The concentration was higher, the Intraocular pressure were lower. Toxic reaction decreased like below： 10 μmol/L 〉 5 μmol/L 〉 0.5 μmol/L 〉 Sodium Chloride. Conclusion Eligible concentration ATO can be used in trabeculectomy to antiscar without evident toxic reaction.

关 键 词：三氧化二砷 抗瘢痕作用 兔眼 小梁切除术 动物实验 

分 类 号：R775.2[医药卫生—眼科]