宫颈鳞癌组织中Survivin和p53蛋白的表达及其临床意义  

Expression of sunvivin and p53 in cervical carcinoma and its clinical significance

作　　者：干晓琴[1] 赵纯全[1] 姬立芹[1] 

机构地区：[1]重庆医科大学附属第一医院妇产科,重庆400016

出　　处：《重庆医科大学学报》2007年第7期702-704,730,共4页Journal of Chongqing Medical University

摘　　要：目的:探讨宫颈鳞癌组织中Survivin和p53蛋白的表达及其临床意义。方法:采用免疫组化SP法检测60例宫颈鳞癌组织中Survivin和p53蛋白的表达情况,并结合临床病理特征进行分析。结果:Survivin和p53在宫颈鳞癌中的表达阳性率分别为90%、53.33%。Survivin的表达与患者的年龄、分化程度、新辅助化疗及有无淋巴结转移无关,但与临床分期显著相关。p53蛋白的表达与患者的年龄、分化程度无关,但与临床分期、是否进行新辅助化疗及有无淋巴结转移显著相关。Survivin和p53在宫颈鳞癌中共同表达阳性率为51.67%,尤其是术前进行了新辅助化疗或伴转移的病例中,二者的共同表达阳性率更高,分别为85%和91.67%。结论:Survivin和p53可能参与了宫颈癌的演进和恶化,两者可能起协同作用。Objective：To investigate the clinical significance of the expression of Survivin and p53 in cervical carcinoma. Methods：Expression of Survivin and p53 in sixty paraffin-embedded specimens of cervical carcinoma patients were examined by using the immunohistochemistry method. Results：The positive expressions rates of Survivin and p53 in sixty cervical carcinoma specimens were 90% ,53.33% respectively. The positive expressions of Survivin were not associated with age,differentiation grade,neoadjuvant chemotherapy and lymph node metastasis, but were highly associated with clinical stage. The positive expressions of p53 were not associated with age and differentiation gTade,but highly associated with clinical stage,neoadjuvant chemotherapy and lymph node metastasis. The positive rate of the co-expression of Survivin and p53 in sixty specimens was 51.67% ,and it was especially higher in the patients who experienced neoadjuvant chemotherapy （85%）or had lymph node metastasis （91.67%）. Conclusions：The expressions of Survivin and p53 in cervical carcinoma might cooperatively play an important role in the progression and deterioration of cervical carcinoma.

关 键 词：宫颈鳞癌/病理学 基因表达 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]