早期糖尿病视网膜病变患者视网膜微循环状况的分析  

An analysis of retinal microcirculation status on patients with early stage diabetic retinopathy

作　　者：张苑苑 郭自元 雷嘉启[2] 

机构地区：[1]秦皇岛市视光眼科医院,秦皇岛066000 [2]北京大学第三医院眼科

出　　处：《中国中医眼科杂志》2007年第3期128-130,共3页China Journal of Chinese Ophthalmology

摘　　要：目的观察早期糖尿病视网膜病变患者中发生视网膜毛细血管无灌注区的特点和构成比。方法观察对象为有1次以上荧光素眼底血管造影检查和眼底彩色照相资料,并明确诊断为Ⅰ期和Ⅱ期糖尿病视网膜病变患者,除外其他眼底病变和影响眼底检查的屈光间质病变。微血管瘤、视网膜出血和毛细血管无灌注区以荧光素眼底血管造影检查和眼底照片为准。无灌注区长径小于1/3视盘直径者未列入统计。结果符合统计标准的观察病例316例,男性139例(44.0%),女性177例(56.0%)。平均年龄56.8岁。接受检查距发现患病的时间平均为7.9年,时间中位数为4年。统计病例中有1次检查记录者289例,2次记录者18例,3次记录者9例。接受检查前最后一次检查空腹血糖水平4.6～12.8(平均数±标准差为9.1±2.8mmol/L)。316例患者632只眼中排除未得到眼底照片者,实际统计眼数为609只眼。其中Ⅰ期病变256只眼中毛细血管无灌注区者33只眼(12.89%),Ⅱ期病变353只眼中毛细血管无灌注区者为144只眼(40.79%)。结论及时发现糖尿病视网膜病变Ⅰ期和Ⅱ期患眼中存在包括视网膜毛细血管无灌注区在内的微循环异常对有效保护视功能具有重要意义。OBJECTIVE To investigate characters and ratio of retinal capillary nonperfusion in patients with early stage diabetic retinopathy.METHODS The data from patents with diabetic retinopathy diagnosed definitively as stage Ⅰ and stage Ⅱ were reviewed retrospectively according to fluorescein fundus angiography and color photo. When major diameter of capillary nonperfusion was less than one third of optic disc diameter, the eyes were not included. RESULTS Three hundred and sixteen patients accorded with statistical criterion including 139 men and 177women.The average age was 56.8 years.The average period from detedtion to examination was 7.9 years（average 4 years）.Six hundred and nine eyes were included virtually.There were 33 eyes（ 12.89 % ）with capillary nonperfusion in the 256 eyes with stage Ⅰ , and 144 eyes（40.79 % ）in the 353 eyes with stage Ⅱ . CONCLUSIONS Intraretinal microvascular abnormality including capillary nonperfusion has eecurred virtually in the considerable eyes with diabetic retinopathy as stage Ⅰ and stage Ⅱ.

关 键 词：糖尿病视网膜病变 视网膜微循环 毛细血管 视功能 

分 类 号：R770.43[医药卫生—眼科] R774.1[医药卫生—临床医学]