2-氯腺苷的合成路线研究  

Study on Synthetic Route of 2-Chloroadenosine

作　　者：申艳红[1] 张文生[1] 冯峰[1] 渠桂荣[1] 

机构地区：[1]河南师范大学化学与环境科学学院

出　　处：《精细与专用化学品》2007年第12期14-15,共2页Fine and Specialty Chemicals

基　　金：国家自然科学基金资助项目(No:20372018)

摘　　要：以2-氯腺嘌呤和1,2,3,5-四乙酰基核糖为原料,四氯化锡为催化剂,在130℃下反应15min,得到中间体2-氯腺嘌呤-2’,3’,5’-三乙酰基核苷。室温下用氨的甲醇饱和溶液脱酰基,在乙醇中进行结晶,得到白色2-氯腺苷粉状晶体,收率70.2%,纯度(HPLC)≥99.0?,155℃发生分解。Using tin tetrachloride as catalyst, 2-chloroadenine reacted with 1,2,3,5-tetraacetylribofuranose at 130 ℃for 15 minutes to form the intermediate 2＇ ,3＇ ,5＇ -triacetylnucleoside-2-chloroadenosine. The intermediate was deamidation in NH3 saturated methanol solution at room temperature and the product 2-chloroadonosine crystallized out from ethanol to give a white powder-like crystal with a yield of 70.2% and purity （HPLC） I〉99.0%. The melting point of the product was not detected as it could be decomposed at 155℃.

关 键 词：2-氯腺苷 2-氯腺嘌呤 1 2 3 5-四乙酰基核糖 四氯化锡 

分 类 号：TQ464[化学工程—制药化工]