抑肽酶对大鼠肝脏缺血再灌注损伤的保护作用  

Prodective Mechanism of Aprotinin on Liver Ischemia Reperfusion Injury in Rats

作　　者：胡玉文[1] 陈国富[1] 范国华[1] 

机构地区：[1]哈尔滨医科大学附属第五医院普外科,黑龙江大庆163316

出　　处：《中国伤残医学》2007年第3期12-13,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨抑肽酶对大鼠肝脏缺血再灌注损伤的保护作用。方法:将48只Wastar大鼠随机分成假手术组、缺血再灌入组和预防性抑肽酶组,检测不同时间血浆或肝组织中谷丙转氨酶(ALT)、丙二醛(MDA)和超氧化物歧化酶(SOD)含量变化及肝组织病理变化。结果:用抑肽酶处理组大鼠血清ALT及肝组织中MDA含量明显低于缺血再灌注(P<0.01)而肝组织中SOD含量则高于缺血再灌注组(P<0.01)肝细胞形态学异常改变较缺血再灌注组也明显减轻。结论:抑肽酶对大鼠肝脏缺血再灌注损伤起保护作用。Objective. To study the protective mechanism of aprotinin on liver ischemiareperfusion injury in rats. Methods： 48 male Wistar rats were randomly divided into sham operated contral group, ischemia-reperfusion group and aprotinin pretreatment group.ALT level in the blood and levels of MDA and SOD in liver tissue in each group were detected at several times, the hepatic tissue was examined under lightmicroscope. Results： ALT, MDA decreased and SOD increased significantly in aprotinin pretreatment group when compared those in the ischemia group（P〈0.01）.The histotogy changeg of the liver tissue under lightmicroscope in the aprotinin pretreatment group was more lwoer than in the I/R group.Conclusion： The aprotinin have protective effects on liver ischemiareperfusion injury.

关 键 词：肝脏 抑肽酶 缺血再灌注损伤 

分 类 号：R575.3[医药卫生—消化系统]