乳腺肿块^(99m)Tc-MIBI显像规律与其组织病理学关系的初步探讨  

The relationship between the 99m Tc MIBI imaging characteristics and the histopathologic features of breast tumors

作　　者：杜勇[1,2] 任长征[1,2] 龙艳 

机构地区：[1]山东医科大学附属医院核医学科 [2]济南军区总医院干部二科

出　　处：《中华核医学杂志》1997年第1期43-45,共3页Chinese Journal of Nuclear Medicine

摘　　要：为探讨９９ｍＴｃ甲氧基异丁基异腈（ＭＩＢＩ）乳腺显像诊断乳腺癌的临床价值及不同组织病理学特点的显像规律，对８４例乳腺肿块患者行９９ｍＴｃＭＩＢＩ显像检查。肘静脉“弹丸”式注射９９ｍＴｃＭＩＢＩ７４０～９２５ＭＢｑ，动态采集血流相、血池相、５分钟早期摄取相及６０、１２０分钟延迟相图像，并计算病变的早、晚期摄取比值。结果表明：乳腺病变显像特点随组织病理学类型不同而有明显差别。４３例乳腺癌中３７例诊断为阳性，６例假阴性；４１例良性病变中３例有放射性浓集。此法检出乳腺癌的灵敏度、特异性分别为８６０５％和９２６８％。因此，９９ｍＴｃＭＩＢＩ显像对鉴别乳腺良、恶性病变具有重要临床应用价值，但对癌细胞密度低的恶性肿瘤，如硬癌及有多发性坏死而血供不良的恶性肿瘤诊断效果不佳。PURPOSE To evaluate the value of 99m Tc MIBI imaging in the detection of breast carcinomas and to assess the relationship between the histopathologic features of the lesions and their imaging characteristics METHODS 84 female patients with palpable breast masses underwent 99m Tc MIBI breast scintigraphy The early and delay images were acquired at 2～4, 5, 60 and 120min after injection of 740～925MBq 99m Tc MIBI intravenously RESULTS 37 of the 43 cases of breast carcinomas were detected by 99m Tc MIBI scintigraphy, meanwhile the histopathologic features of the lesions greatly influenced their imaging characteristics The diagnostic sensitivity, specificity were 86 05% and 92 68%, respectively CONCLUSIONS 99m Tc MIBI breast scintigraphy is useful for differentiating malignancies from benign breast masses, but false negatives may occur in certain lesions with poor conditions of vascularity and cellularity

关 键 词：乳腺肿瘤 组织病理学 ^99MTC MIBI 

分 类 号：R737.902[医药卫生—肿瘤]