治疗剂量^(153)Sm-EDTMP骨显像效果评价及临床应用  

Clinical Application and Evaluation of the Effect of Therapeutic Dose ^(153)Sm-EDTMP in Skeleton Imaging

作　　者：陈钰[1] 曹春晓[1] 汪建强[1] 罗远文 

机构地区：[1]宜宾市第二人民医院,四川宜宾644000

出　　处：《实用医技杂志》2007年第14期1811-1812,共2页Journal of Practical Medical Techniques

基　　金：宜宾市重点科技计划项目(200403010)

摘　　要：目的:量化评价治疗剂量153Sm-EDTMP骨显像的效果并探讨其显像条件和临床应用范围。方法:肿瘤骨转移患者52例,99Tcm-MDP骨显像后3d～12d内首次接受153Sm-EDTMP内放射治疗并行153Sm-EDTMP骨显像,将两种骨显像效果进行目测比较,以感兴趣区(ROI)技术分别测得两种显像的M/N比值并将其对数值进行配对资料t检验的统计学处理。结果:治疗剂量153Sm-EDTMP骨显像M/N比值为2.63,高于99Tcm-MDP骨显像M/N比值2.16。治疗剂量153Sm-EDTMP骨显像效果优于99Tcm-MDP。结论:在153Sm-EDTMP治疗骨转移瘤时注射后可直接进行显像观察骨转移病情变化,节省部分骨显像剂99Tcm-MDP的使用。Objective To evaluate the effect of therapeutic dose ^153 Sm-EDTMP in skeleton imaging, to discuss condition of imaging and the range of use. Methods 52 patients with bone metastases treated with ^153 Sm-EDTMP for the first time. ^153 Sm-EDTMP skeleton imaging was taked and compared with ^99 Tc^m.MDP skeleton imaging. The technique of ROI was used and M/ N ratio was taked. The data was analyzed in statistical way. Results The M/N ratio of ^153 Sm-EDTMP skeleton imaging higher than ^99 Tc^m-MDP skeleton imaging. The effect of ^153 Sm-EDTMP skeleton imaging is higher than ^99 Tc^m-MDP skeleton imaging. Conclusion ^153 Sm-EDTMP can be used as imaging agent at the same time, and 99 Tc^m.MDP can be saved.

关 键 词：SPECT ^153Sm—EDTMP 骨显像 

分 类 号：R730.4[医药卫生—肿瘤]