7,8-二氢-5,7,7-三甲基-10-(2-噻吩基)-5H-茚[1,2-b]并喹啉-9,11(6H,10H)-二酮的合成和晶体结构  

Synthesis and Crystal Structure of 7,8-Dihydro-5,7,7-trimethyl-10-(thiophen-2-yl)-5H-indenoquinoline9,11(6H,10H)-dione

作　　者：姜波[1] 贾润红[1] 张艳[1] 张俊勇[1] 

机构地区：[1]徐州师范大学化学化工学院,江苏徐州221116

出　　处：《徐州师范大学学报（自然科学版）》2007年第2期61-64,共4页Journal of Xuzhou Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目资助(20372057);徐州师范大学研究生科研课题立项项目资助(06YL004)

摘　　要：以2-噻吩醛,5,5-二甲基-3-甲氨基环己-2-烯酮和1,3-茚二酮为原料,在醋酸溶剂中,通过微波辅助的多组分反应一步合成标题化合物.结构经红外光谱、核磁共振和元素分析得以确证,并通过单晶X射线衍射进一步确证.其晶体属于三斜晶系,空间群P-1,a=0.728 7(4),b=0.852 7(4),c=1.554 6(8)nm,α=90.514(10)°,β=91.579(9)°,γ=92.251(9)°,Mr=375.47,V=0.964 8(8)nm3,Dc=1.292 g/cm3,Z=2,μ(Mo Kα)=0.185 mm-1,F(000)=396.晶体结构用直接法解出,使用全矩阵最小二乘法对原子参数进行修正,最后的偏离因子R=0.090 6,Rw=0.169 2.The title compound has been synthesized via microwave-assisted multicomponent reaction of thiophene-2-carbaldehyde with 5, 5-dimethyl-3-（methylamino） cyclohex-2-enone and 1,3-indanedione in HOAc, and its structure was determined by monocrystalline X-ray diffraction. The crys- tal is triclinic, space group P-1 with a=0.728 7（4）, b=0.852 7（4）, c=1.554 6（8） nm, a= 90.514（10）°, β=91.579（9）°, r=92.251（9）°, Mr=375.47, V=0.964 8（8） nm^3, Dc=l.292 g/cm^3, Z=2, μ（Mo Ka）=0.185 mm^-1 , F（000）=396. The structure was solved by direct methods and refined by the full-matrix method of least-squares to the final R=0.090 6, Rw =0.169 2.

关 键 词：微波合成 晶体结构 多组分反应 

分 类 号：O625[理学—有机化学]