7-(3-芳基)丙烯酰氧基-4-甲基香豆素的合成  

Synthesis of 7-(3-Aryl)acryloxy-4-methyl Coumarins

作　　者：严春临[1] 张季[1] 杨树平[2] 

机构地区：[1]河北北方学院药学系,河北张家口075000 [2]内蒙古医学院药物化学教研室,内蒙古呼和浩特010059

出　　处：《河北北方学院学报（自然科学版）》2007年第2期17-19,27,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：合成7-(3-芳基)丙烯酰氧基-4-甲基香豆素类化合物.方法:以酰氯法,经酯化反应,制得7种相应香豆素类化合物.结果:结构经元素分析、红外光谱、紫外光谱确定7种化合物(Ⅲa—Ⅲg)未见文献报道.结论:用酰氯法制备7-(3-芳基)丙烯酰氧基-4-甲基香豆素类化合物是简便易行的.Objective： The purpose is to synthesize 7-（3-Aryl） acryloxy-4-methyl Coumarins. Methods, Compounds were obtained from the reaction of 7-Hydroxy-4-methyl Coumarins with substituted cinnamic acid. Results. A series of 7-（3-Aryl） acryloxy-4-methyl Coumarins were synthesized. Their structures were unreported and unidentified by IR, UV and elemental analysis data. Conclusion- The method of synthesizing 7-（3-Aryl） acryloxy-4-methyl Coumarins is simple, convenient and feasible.

关 键 词：香豆素 肉桂酸 药物合成 

分 类 号：R914.5[医药卫生—药物化学]