可能Wolffian管起源的女性附件肿瘤临床病理分析  

Female adnexal tumor of probable Wolffian origin(FATWO):report of four cases and review of literature

作　　者：于宁[1] 张廷国[1] 王妍[1] 李盛梅[1] 王美清[1] 

机构地区：[1]山东大学齐鲁医院病理科,济南250012

出　　处：《现代妇产科进展》2007年第5期348-350,I0001,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨可能Wolffian管起源的女性附件肿瘤临床病理特征和诊断要点。方法:用光镜、组织化学及免疫组化方法研究了4例此类肿瘤,探讨其组织病理学表现。结果:此类肿瘤多位于阔韧带或输卵管系膜,即Wolffian管残留处;肿瘤细胞可排列成实性分叶状、小管状或筛网状;免疫表型示CK(AE1/AE3)、CD10、CD99和弹性蛋白(Vimen-tin)阳性,α-抑制素部分阳性、EMA阴性。组织化学染色示PAS基底膜阳性。结论:可能Woliffian管起源的女性附件肿瘤是罕见的肿瘤,诊断基于其特征性的组织学特点和发生部位,应与支持-间质细胞瘤、透明细胞瘤、粒层细胞瘤等鉴别。Objective：To study the clinical and pathological features of female adnexal tumor of probable Wolffian origin. Method：Light microscopy, histochemistry and immunohistochemistry methods were utilized to study the features of the histopathology of female adnexal tumor of probable Wolffian origin. Results： The tumor was located in the areas where Wolffian duct remnants were found （unilaterally located in the broad ligament, mesosalpinx, ovarian hilum）. They showed varying morphologies with solid, tubular, and retiform patterns. Positive stain was found by immunohistochemistry assay for cytokeratin （AE1/AE3 ）, CD10, CD99 and vimentin,but not for EMA,some of the cases（3/4） are partly positive for α-inhibin. But negative for EMA. Histochemistry showed positive for basement membrane expression of PAS. Conclusions：Female adnexal tumor of probable Wolffian origin is rare, which is diagnosised by its histological features and it＇s distinctive location where Wolffian duct renmants axe found, and the differential diagnosis of this tumor includes Sertoli-Leydig cell tumors, clear cell tumors and granulose cell tumors.

关 键 词：沃尔夫管 子宫附件肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]