C-met表达与肝细胞癌分化程度的关系研究  

The expression of C-met in hepatocellular carcinoma

作　　者：黄斌[1] 陈杰[2] 朱勇[1] 陈历恒 王景泉[2] 

机构地区：[1]四川省宜宾市第二人民医院肝胆外科,644000 [2]首都医科大学附属北京佑安医院

出　　处：《实用肝脏病杂志》2007年第3期155-156,共2页Journal of Practical Hepatology

摘　　要：目的探讨不同分化程度肝癌组织中的C-met的表达。方法选取我院外科切除的42例肝细胞癌组织,按分化程度分为高分化组及中低分化组,另选10例正常肝组织作为对照。免疫组织化学S-P法测定C-met表达。结果23例中低分化肝癌病例中,19例(82.6%)呈阳性反应;19例高分化肝癌病例中,9例(47.7%)呈阳性反应;10例对照病例中,仅有1例为阳性。中低分化肝癌组的C-met阳性率高于正常对照和高分化肝癌组。结论C-met在中低分化肝癌中存在高表达。Objective To study the expression of C-met in hepatocellular carcinoma. Methods Tumor tissues from 42 patients with hepatocellular carcinoma were divided into high differentiation group and middle/low differentiation group and 10 liver tissue specimens from health persons were taken as control. Immunohistochemical staining were adopted to detect the expression of C-met. Results The positive rate of C-met in middle/low differentiation group was higher than in high differentiation group （82.6% vs. 47.7%, P〈0.01）. Conclusion C-met is overexpressed in middle/low differentiated hepatocellular carcinoma.

关 键 词：肝细胞癌 C—met 免疫组化 

分 类 号：R735.7[医药卫生—肿瘤]