环氧合酶-2及其抑制剂与肿瘤多药耐药  

Cyclooxygenase-2 and its inhibitor and multidrug resistance

作　　者：张玲[1] 陈同钰[1] 

机构地区：[1]苏州大学附属第三医院病理科,江苏常州213003

出　　处：《国外医学（药学分册）》2007年第3期177-180,共4页Foreign Medical Sciences(Section of Pharmarcy)

摘　　要：肿瘤多药耐药是目前化疗失败的最常见且最难解决的问题,环氧合酶-2参与肿瘤的发生发展,近年来一些研究表明,环氧合酶-2与肿瘤多药耐药密切相关,并且通过多条途径参与肿瘤多药耐药的发生,该文对环氧合酶-2及其抑制剂与肿瘤多药耐药的关系做一综述。At present, muhidrug resistance （MDR） is the most common and difficult problem of failure of chemotherapy. Cyclooxygenase-2 （COX-2） participated in the development of tumor. Recently, the study showed that COX-2 was closely related to muhidrug resistance of turners and played an important role in the development of MDR through many paths. In this article the relationship between COX-2 and MDR is reviewed.

关 键 词：环氧合酶-2 P糖蛋白 肿瘤多药耐药 

分 类 号：R730.5[医药卫生—肿瘤]